123I-FP-CIT SPECT imaging of dopamine transporters in patients with recurrent sudden falls: Are such falls a distinct entity?

Ruth Djaldetti, Therese A. Treves, Ilan Ziv, Eldad Melamed, Mordechai Lorberboym

Research output: Contribution to journalArticlepeer-review

Abstract

Recurrent falls in older people are commonly associated with abnormalities that involve several parts of the central nervous system, especially with basal ganglion pathology. The aim of the present studywas to evaluate the integrity of striatal dopamine transporters (DaTs) by use of 123I-N-3- fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)tropane ( 123I-FP-CIT) SPECT of striatal DaTs in patients with recurrent sudden falls. Methods: Twenty-one patients without a definite neurologic diagnosis for recurrent sudden falls were enrolled in a cross-sectional study. SPECT with a DaT ligand was performed 180 min after injection of 185 MBq of 123I-FP-CIT with a dual-head γ-camera. Results: DaT SPECT findings were normal in 15 of 21 patients (71%). Of those, 73% had abnormal MRI findings suggestive of atherosclerotic lesions. Eleven patients with normal DaT SPECT findings had mild parkinsonian symptoms. There was no correlation of the SPECT results with patient age, duration of occurrence of falls, or frequency of falls, and there was no significant difference in the relative distributions of SPECT findings between patients with and patients without parkinsonian symptoms or vascular risk factors. Conclusion: Recurrent sudden falls are, inmost cases, not attributable to the degeneration of the nigrostriatal system.

Original languageEnglish
Pages (from-to)232-236
Number of pages5
JournalJournal of Nuclear Medicine Technology
Volume35
Issue number4
DOIs
StatePublished - Dec 2007

Keywords

  • Dopamine transporters
  • Parkinsonism
  • Recurrent falls
  • SPECT

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