TY - JOUR
T1 - Sulfated Glycoprotein‐2 Induced Endogenous Resistance to Ischemia and Reperfusion Injury in the Seminiferous Tubules
AU - LEIBOVITCH, ILAN
AU - BUTTYAN, RALPH
PY - 1991/10
Y1 - 1991/10
N2 - ABSTRACT: Evidence of increased resistance of Sertoli cells to ischemia and reperfusion injury was presented by numerous histological, morphological, and quantitative studies. In situ hybridization techniques and immunocytochemical studies demonstrated intense expression of sulfated glycoprotein‐2 (SGP‐2) in Sertoli cells. We propose that protective effects of SGP‐2 are the core of the differential tolerance of ischemia by the various testicular cells and the morphology of the postischemic testis. We believe that suppression of ischemic damage selectively in Sertoli cells is the consequence of the ability to produce SGP‐2, an endogenous inhibitor of ischemic injury. This hypothetical function of SGP‐2 is supported by its immunosuppressive properties and its structural and functional identity to several types of human complement cytolysis inhibitors. 1991 Munksgaard
AB - ABSTRACT: Evidence of increased resistance of Sertoli cells to ischemia and reperfusion injury was presented by numerous histological, morphological, and quantitative studies. In situ hybridization techniques and immunocytochemical studies demonstrated intense expression of sulfated glycoprotein‐2 (SGP‐2) in Sertoli cells. We propose that protective effects of SGP‐2 are the core of the differential tolerance of ischemia by the various testicular cells and the morphology of the postischemic testis. We believe that suppression of ischemic damage selectively in Sertoli cells is the consequence of the ability to produce SGP‐2, an endogenous inhibitor of ischemic injury. This hypothetical function of SGP‐2 is supported by its immunosuppressive properties and its structural and functional identity to several types of human complement cytolysis inhibitors. 1991 Munksgaard
KW - Sertoli cells
KW - Sulfated glycoprotein‐2
KW - ischemia reperfusion injury
KW - seminiferous tubules
KW - testis
UR - http://www.scopus.com/inward/record.url?scp=0026357045&partnerID=8YFLogxK
U2 - 10.1111/j.1600-0897.1991.tb00707.x
DO - 10.1111/j.1600-0897.1991.tb00707.x
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C2 - 1805859
AN - SCOPUS:0026357045
SN - 1046-7408
VL - 26
SP - 114
EP - 117
JO - American Journal of Reproductive Immunology
JF - American Journal of Reproductive Immunology
IS - 3
ER -