Suicidal thoughts in patients with Parkinson's disease treated by deep brain stimulation of the subthalamic nuclei: Two case reports and review of the literature

Yacov Balash*, Doron Merims, Nir Giladi

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

Background: Deep brain stimulation (DBS) of the subthalamic nuclei (STN) can result in depression despite the obvious motor improvement. Case presentations: Two patients with serious life-threatening depressive episodes are described. In the first case, the trigger for depression was a slight adjustment of the left stimulating electrode's contact. In the second case, reducing both the dopaminergic therapy and the voltage of DBS resulted in the manifestation of depressive symptoms. Conclusions: DBS-induced depression possibly has pathogenetic differences from ordinary Parkinson's disease depression. The STN region seems to be a sensitive zone that influences emotions.

Original languageEnglish
Pages (from-to)208-210
Number of pages3
JournalActa Neuropsychiatrica
Volume19
Issue number3
DOIs
StatePublished - Jun 2007

Keywords

  • Deep brain stimulation
  • Depression
  • Parkinson's disease
  • Subthalamic nuclei
  • Suicidal thoughts

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