Successful treatment of prolonged agranulocytosis caused by acute parvovirus B19 infection with intravenous immunoglobulins

K. Herzog-Tzarfati; E. Shiloah; M. Koren-Michowitz; S. Minha; M. J. Rapoport

doi:10.1016/j.ejim.2006.02.014

Successful treatment of prolonged agranulocytosis caused by acute parvovirus B19 infection with intravenous immunoglobulins

K. Herzog-Tzarfati, E. Shiloah^*, M. Koren-Michowitz, S. Minha, M. J. Rapoport

^*Corresponding author for this work

Tel Aviv University

Research output: Contribution to journal › Article › peer-review

16 Scopus citations

Abstract

A 21-year-old previously healthy male presented with prolonged fever of 3 weeks duration and profound agranulocytosis that did not respond to treatment with granulocyte-stimulating factors. A bone marrow biopsy demonstrated an absence of myeloid lineage. Acute parvovirus B19 infection was diagnosed by the presence of both IgM and IgG anti-parvovirus antibodies. Two days treatment with intravenous immunoglobulins (IVIg) resulted in complete recovery. The role of treatment with immunoglobulins in acute and persistent parvovirus infection is discussed.

Original language	English
Pages (from-to)	439-440
Number of pages	2
Journal	European Journal of Internal Medicine
Volume	17
Issue number	6
DOIs	https://doi.org/10.1016/j.ejim.2006.02.014
State	Published - Oct 2006

Keywords

Agranulocytosis
Intravenous immunoglobulin
Parvovirus B19

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10.1016/j.ejim.2006.02.014

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title = "Successful treatment of prolonged agranulocytosis caused by acute parvovirus B19 infection with intravenous immunoglobulins",

abstract = "A 21-year-old previously healthy male presented with prolonged fever of 3 weeks duration and profound agranulocytosis that did not respond to treatment with granulocyte-stimulating factors. A bone marrow biopsy demonstrated an absence of myeloid lineage. Acute parvovirus B19 infection was diagnosed by the presence of both IgM and IgG anti-parvovirus antibodies. Two days treatment with intravenous immunoglobulins (IVIg) resulted in complete recovery. The role of treatment with immunoglobulins in acute and persistent parvovirus infection is discussed.",

keywords = "Agranulocytosis, Intravenous immunoglobulin, Parvovirus B19",

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AU - Herzog-Tzarfati, K.

AU - Shiloah, E.

AU - Koren-Michowitz, M.

AU - Minha, S.

AU - Rapoport, M. J.

PY - 2006/10

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N2 - A 21-year-old previously healthy male presented with prolonged fever of 3 weeks duration and profound agranulocytosis that did not respond to treatment with granulocyte-stimulating factors. A bone marrow biopsy demonstrated an absence of myeloid lineage. Acute parvovirus B19 infection was diagnosed by the presence of both IgM and IgG anti-parvovirus antibodies. Two days treatment with intravenous immunoglobulins (IVIg) resulted in complete recovery. The role of treatment with immunoglobulins in acute and persistent parvovirus infection is discussed.

AB - A 21-year-old previously healthy male presented with prolonged fever of 3 weeks duration and profound agranulocytosis that did not respond to treatment with granulocyte-stimulating factors. A bone marrow biopsy demonstrated an absence of myeloid lineage. Acute parvovirus B19 infection was diagnosed by the presence of both IgM and IgG anti-parvovirus antibodies. Two days treatment with intravenous immunoglobulins (IVIg) resulted in complete recovery. The role of treatment with immunoglobulins in acute and persistent parvovirus infection is discussed.

KW - Agranulocytosis

KW - Intravenous immunoglobulin

KW - Parvovirus B19

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JO - European Journal of Internal Medicine

JF - European Journal of Internal Medicine

IS - 6

ER -

Successful treatment of prolonged agranulocytosis caused by acute parvovirus B19 infection with intravenous immunoglobulins

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