TY - JOUR
T1 - Successful treatment of early secondary myelofibrosis in SLE with IVIG
AU - Aharon, A.
AU - Levy, Y.
AU - Bar-Dayan, Y.
AU - Afek, A.
AU - Zandman-Goddard, G.
AU - Skurnik, Y.
AU - Fabrrizzi, F.
AU - Shoenfeld, Y.
PY - 1997
Y1 - 1997
N2 - Myelofibrosis has been reported as a rare cause of pancytopenia in patients with autoimmune diseases. We describe a 54 y old female patient who was admitted with severe anemia subsequently found to be due to marrow fibrosis. During the course of her hospitalization, relying both on her clinical symptoms as well as the results of a wide range of laboratory tests and diagnostic procedures, the diagnosis of systemic lupus erythematosus was established. The patient was treated with high dose steroids, but improvement of her clinical symptoms as well as normalization of her peripheral blood count were achieved only after high dose intravenous therapy with gamma globulin (IVIG) was instituted. Along with the improvement in the peripheral blood parameters normalization of the bone marrow architecture was recorded on a repeated bone marrow biopsy. IVIG therapy should be considered in extreme cases of bone marrow suppression in SLE.
AB - Myelofibrosis has been reported as a rare cause of pancytopenia in patients with autoimmune diseases. We describe a 54 y old female patient who was admitted with severe anemia subsequently found to be due to marrow fibrosis. During the course of her hospitalization, relying both on her clinical symptoms as well as the results of a wide range of laboratory tests and diagnostic procedures, the diagnosis of systemic lupus erythematosus was established. The patient was treated with high dose steroids, but improvement of her clinical symptoms as well as normalization of her peripheral blood count were achieved only after high dose intravenous therapy with gamma globulin (IVIG) was instituted. Along with the improvement in the peripheral blood parameters normalization of the bone marrow architecture was recorded on a repeated bone marrow biopsy. IVIG therapy should be considered in extreme cases of bone marrow suppression in SLE.
KW - Intravenous immunoglobulin
KW - Secondary myelofibrosis
KW - Systemic lupus erythematosus
UR - http://www.scopus.com/inward/record.url?scp=0030958502&partnerID=8YFLogxK
U2 - 10.1177/096120339700600412
DO - 10.1177/096120339700600412
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AN - SCOPUS:0030958502
SN - 0961-2033
VL - 6
SP - 408
EP - 411
JO - Lupus
JF - Lupus
IS - 4
ER -