TY - JOUR
T1 - Successful therapeutic splenectomy in an HIV patient with relapsing visceral leishmaniasis
AU - Alon, D.
AU - Chowers, M.
PY - 2012/4
Y1 - 2012/4
N2 - Summary: A 43-year-old HIV-positive Ethiopian immigrant presented with persistent diarrhoea, hepatosplenomegaly and pancytopaenia. Visceral leishmaniasis was diagnosed by multiple gastrointestinal tract biopsies. Blood polymerase chain reaction (PCR) was positive for Leishmania donovani. Despite highly active antiretroviral therapy (HAART) and multiple courses of antileishmanial treatments, including liposomal amphotericin and sodium stibogluconate, the patient had multiple relapses. CD4 counts remained at 40-60 cells/μL although viral loads were undetectable. Splenectomy resulted in resolution of the patient's pancytopaenia and in rising CD4 levels, which enabled a long-lasting remission.
AB - Summary: A 43-year-old HIV-positive Ethiopian immigrant presented with persistent diarrhoea, hepatosplenomegaly and pancytopaenia. Visceral leishmaniasis was diagnosed by multiple gastrointestinal tract biopsies. Blood polymerase chain reaction (PCR) was positive for Leishmania donovani. Despite highly active antiretroviral therapy (HAART) and multiple courses of antileishmanial treatments, including liposomal amphotericin and sodium stibogluconate, the patient had multiple relapses. CD4 counts remained at 40-60 cells/μL although viral loads were undetectable. Splenectomy resulted in resolution of the patient's pancytopaenia and in rising CD4 levels, which enabled a long-lasting remission.
KW - HIV
KW - Leishmania donovani
KW - Splenectomy
KW - Visceral leishmaniasis
UR - http://www.scopus.com/inward/record.url?scp=84861545006&partnerID=8YFLogxK
U2 - 10.1258/ijsa.2009.009234
DO - 10.1258/ijsa.2009.009234
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C2 - 22581957
AN - SCOPUS:84861545006
SN - 0956-4624
VL - 23
SP - 289
EP - 290
JO - International Journal of STD and AIDS
JF - International Journal of STD and AIDS
IS - 4
ER -
