Successful mobilization, harvest and transplant of peripheral blood stem cells using AMD3100 and G-CSF following high dose craniospinal irradiation for medulloblastoma in a young child

Helen Toledano, Anat Yahel, Ian J. Cohen, Isaac Yaniv, Jerry Stein

Research output: Contribution to journalArticlepeer-review

Abstract

Contemporary protocols for the treatment of malignant brain tumors such as medulloblastoma (MB) in children, often involve craniospinal irradiation (CSI) at diagnosis followed by serial courses of high dose chemotherapy and autologous hematopoietic stem cell support. Patients often require several pheresis procedures in order to collect sufficient stem cells for this type of treatment, particularly if they have already had CSI. We describe the successful mobilization, collection and subsequent transplant of a 7-year-old female with medulloblastoma after recent CSI using granulocyte colony stimulating factor (G-CSF) and the CXCR4 antagonist AMD3100 after a failed previous mobilization attempt using G-CSF alone.

Original languageEnglish
Pages (from-to)613-615
Number of pages3
JournalPediatric Blood and Cancer
Volume54
Issue number4
DOIs
StatePublished - Apr 2010

Keywords

  • AMD3100
  • Craniospinal irradiation
  • Medulloblastoma
  • Peripheral blood stem cell mobilization

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