Successful haploidentical bone marrow transplantation in Fanconi anemia

R. Elhasid; M. Weyl Ben Arush; T. Katz; Y. Gan; Y. Shechter; I. Sami; S. Postovsky; Y. Reisner; J. M. Rowe

doi:10.1038/sj.bmt.1702701

Successful haploidentical bone marrow transplantation in Fanconi anemia

R. Elhasid^*, M. Weyl Ben Arush, T. Katz, Y. Gan, Y. Shechter, I. Sami, S. Postovsky, Y. Reisner, J. M. Rowe

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available.

Original language	English
Pages (from-to)	1221-1223
Number of pages	3
Journal	Bone Marrow Transplantation
Volume	26
Issue number	11
DOIs	https://doi.org/10.1038/sj.bmt.1702701
State	Published - 2000
Externally published	Yes

Keywords

Fanconi anemia
Haploidentical bone marrow transplantation

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10.1038/sj.bmt.1702701

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abstract = "A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available.",

keywords = "Fanconi anemia, Haploidentical bone marrow transplantation",

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AU - Elhasid, R.

AU - Ben Arush, M. Weyl

AU - Katz, T.

AU - Gan, Y.

AU - Shechter, Y.

AU - Sami, I.

AU - Postovsky, S.

AU - Reisner, Y.

AU - Rowe, J. M.

PY - 2000

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AB - A 10-year-old girl with Fanconi anemia and severe aplastic anemia underwent a haploidentical BMT from her mother due to lack of a matched family donor. T cell depletion was done by positive selection of CD34 cells with immunomagnetic beads. Due to graft rejection a second haploidentical BMT from the father was successfully undertaken. No immunosuppression was given after the transplant. Immunological reconstitution took approximately 6 months, with no GVHD or severe infections. Such a transplant, containing a large purified CD34 cell fraction with a minimal number of added T cells, should be considered as the treatment of choice for patients with Fanconi anemia if no HLA matched donor is available.

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Successful haploidentical bone marrow transplantation in Fanconi anemia

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