Substance K: Vascular and cardiac effects in rat and pig

J. Eimerl; M. A. Bayorh; Z. Zukowska-Grojec; A. I. Faden; D. Ezra; G. Feuerstein

doi:10.1016/0196-9781(85)90148-2

Substance K: Vascular and cardiac effects in rat and pig

J. Eimerl, M. A. Bayorh, Z. Zukowska-Grojec, A. I. Faden, D. Ezra, G. Feuerstein^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The effects of substance K (SK), a newly discovered tachykinin, on the cardiovascular and sympathetic system were evaluated in the pithed rat preparation and in the in situ domestic pig heart. In pithed rats, SK (10 nmol/kg, IV) produced a triphasic mean blood pressure (MAP) response: short depressor, short pressor (+11±1 mmHg), and prolonged depressor phase (-9±1 mmHg, n=9-24, p<0.001). Neither effect was significantly affected by pretreatment with propranolol (2 mg/kg) or phentolamine (1 mg/kg). The pressor response was accompanied by increased heart rate (HR): 41±4 beats/min, while lower doses produced a decrease: -8±2 beats/min (p<0.01). Propranolol abolished the increase in HR. SK inhibited the pressor response evoked by electrical stimulation of the spinal cord (SCS) and by Arg⁸-vasopressin (AVP). SK increased circulating levels of epinephrine and norepinephrine but did not change release of catecholamines evoked by SCS. Direct intracoronary injections of SK (0.3-100 nmol, intact pig heart) increased coronary blood flow; higher doses decreased MAP and increased HR. These results indicate that: (1) SK can produce pressor and depressor effects in the rat and is a potent coronary dilator in the pig. (2) In the pithed rat SK causes catecholamine release which mediates its cardiac accelerator effect and it antagonizes adrenergic and non-adrenergic pressor stimuli.

Original language	English
Pages (from-to)	149-153
Number of pages	5
Journal	Peptides
Volume	6
Issue number	SUPPL. 2
DOIs	https://doi.org/10.1016/0196-9781(85)90148-2
State	Published - 1985
Externally published	Yes

Funding

Funders	Funder number
Uniformed Services University of the Health Sciences	R09211

Keywords

Blood pressure
Catecholamines
Coronary blood flow
Heart rate
Neuromedins
Pithed rat
Substance K
Tachykinins

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/0196-9781(85)90148-2

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@article{2fef09f7676a41d3aa4d381e8bfcb7a7,

title = "Substance K: Vascular and cardiac effects in rat and pig",

abstract = "The effects of substance K (SK), a newly discovered tachykinin, on the cardiovascular and sympathetic system were evaluated in the pithed rat preparation and in the in situ domestic pig heart. In pithed rats, SK (10 nmol/kg, IV) produced a triphasic mean blood pressure (MAP) response: short depressor, short pressor (+11±1 mmHg), and prolonged depressor phase (-9±1 mmHg, n=9-24, p<0.001). Neither effect was significantly affected by pretreatment with propranolol (2 mg/kg) or phentolamine (1 mg/kg). The pressor response was accompanied by increased heart rate (HR): 41±4 beats/min, while lower doses produced a decrease: -8±2 beats/min (p<0.01). Propranolol abolished the increase in HR. SK inhibited the pressor response evoked by electrical stimulation of the spinal cord (SCS) and by Arg8-vasopressin (AVP). SK increased circulating levels of epinephrine and norepinephrine but did not change release of catecholamines evoked by SCS. Direct intracoronary injections of SK (0.3-100 nmol, intact pig heart) increased coronary blood flow; higher doses decreased MAP and increased HR. These results indicate that: (1) SK can produce pressor and depressor effects in the rat and is a potent coronary dilator in the pig. (2) In the pithed rat SK causes catecholamine release which mediates its cardiac accelerator effect and it antagonizes adrenergic and non-adrenergic pressor stimuli.",

keywords = "Blood pressure, Catecholamines, Coronary blood flow, Heart rate, Neuromedins, Pithed rat, Substance K, Tachykinins",

author = "J. Eimerl and Bayorh, {M. A.} and Z. Zukowska-Grojec and Faden, {A. I.} and D. Ezra and G. Feuerstein",

note = "Funding Information: This work was supportedin part by USUHS Protocol# R09211 for G. FeuersteinM, .D. The opinionso r assertationcso ntainehde rein are the privateo nesof the authorsa nd are not to be construed as officialo r reflectingth eview of the Departmenotf Defenseo r the UniformedS ervicesU niversityo f the HealthS ciencesT. he experi-mentsr eportedh ereinw ere conducteda ccordingto the principles set forthi n the {"}Guidef or the Care and Use of LaboratoryA nimals,'{"} Institute of Laboratory Animal Resources,N ational Research Council (DHEW PublicationN O. (NIH) 78-23, 1978).T he authors wish to thankM s. Mary Mills for her help in preparingth is manuscript.",

year = "1985",

doi = "10.1016/0196-9781(85)90148-2",

language = "אנגלית",

volume = "6",

pages = "149--153",

journal = "Peptides",

issn = "0196-9781",

publisher = "Elsevier Inc.",

number = "SUPPL. 2",

}

TY - JOUR

T1 - Substance K

T2 - Vascular and cardiac effects in rat and pig

AU - Eimerl, J.

AU - Bayorh, M. A.

AU - Zukowska-Grojec, Z.

AU - Faden, A. I.

AU - Ezra, D.

AU - Feuerstein, G.

N1 - Funding Information: This work was supportedin part by USUHS Protocol# R09211 for G. FeuersteinM, .D. The opinionso r assertationcso ntainehde rein are the privateo nesof the authorsa nd are not to be construed as officialo r reflectingth eview of the Departmenotf Defenseo r the UniformedS ervicesU niversityo f the HealthS ciencesT. he experi-mentsr eportedh ereinw ere conducteda ccordingto the principles set forthi n the "Guidef or the Care and Use of LaboratoryA nimals,'" Institute of Laboratory Animal Resources,N ational Research Council (DHEW PublicationN O. (NIH) 78-23, 1978).T he authors wish to thankM s. Mary Mills for her help in preparingth is manuscript.

PY - 1985

Y1 - 1985

N2 - The effects of substance K (SK), a newly discovered tachykinin, on the cardiovascular and sympathetic system were evaluated in the pithed rat preparation and in the in situ domestic pig heart. In pithed rats, SK (10 nmol/kg, IV) produced a triphasic mean blood pressure (MAP) response: short depressor, short pressor (+11±1 mmHg), and prolonged depressor phase (-9±1 mmHg, n=9-24, p<0.001). Neither effect was significantly affected by pretreatment with propranolol (2 mg/kg) or phentolamine (1 mg/kg). The pressor response was accompanied by increased heart rate (HR): 41±4 beats/min, while lower doses produced a decrease: -8±2 beats/min (p<0.01). Propranolol abolished the increase in HR. SK inhibited the pressor response evoked by electrical stimulation of the spinal cord (SCS) and by Arg8-vasopressin (AVP). SK increased circulating levels of epinephrine and norepinephrine but did not change release of catecholamines evoked by SCS. Direct intracoronary injections of SK (0.3-100 nmol, intact pig heart) increased coronary blood flow; higher doses decreased MAP and increased HR. These results indicate that: (1) SK can produce pressor and depressor effects in the rat and is a potent coronary dilator in the pig. (2) In the pithed rat SK causes catecholamine release which mediates its cardiac accelerator effect and it antagonizes adrenergic and non-adrenergic pressor stimuli.

AB - The effects of substance K (SK), a newly discovered tachykinin, on the cardiovascular and sympathetic system were evaluated in the pithed rat preparation and in the in situ domestic pig heart. In pithed rats, SK (10 nmol/kg, IV) produced a triphasic mean blood pressure (MAP) response: short depressor, short pressor (+11±1 mmHg), and prolonged depressor phase (-9±1 mmHg, n=9-24, p<0.001). Neither effect was significantly affected by pretreatment with propranolol (2 mg/kg) or phentolamine (1 mg/kg). The pressor response was accompanied by increased heart rate (HR): 41±4 beats/min, while lower doses produced a decrease: -8±2 beats/min (p<0.01). Propranolol abolished the increase in HR. SK inhibited the pressor response evoked by electrical stimulation of the spinal cord (SCS) and by Arg8-vasopressin (AVP). SK increased circulating levels of epinephrine and norepinephrine but did not change release of catecholamines evoked by SCS. Direct intracoronary injections of SK (0.3-100 nmol, intact pig heart) increased coronary blood flow; higher doses decreased MAP and increased HR. These results indicate that: (1) SK can produce pressor and depressor effects in the rat and is a potent coronary dilator in the pig. (2) In the pithed rat SK causes catecholamine release which mediates its cardiac accelerator effect and it antagonizes adrenergic and non-adrenergic pressor stimuli.

KW - Blood pressure

KW - Catecholamines

KW - Coronary blood flow

KW - Heart rate

KW - Neuromedins

KW - Pithed rat

KW - Substance K

KW - Tachykinins

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SN - 0196-9781

VL - 6

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JO - Peptides

JF - Peptides

IS - SUPPL. 2

ER -

Substance K: Vascular and cardiac effects in rat and pig

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