Subpopulations of marrow stromal cells share a variety of osteoblastic markers

Dafna Benayahu; Adina Fried; Dov Zipori; Shlomo Wientroub

doi:10.1007/BF02556119

Subpopulations of marrow stromal cells share a variety of osteoblastic markers

Dafna Benayahu, Adina Fried, Dov Zipori, Shlomo Wientroub^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

A series of stromal cell lines derived from mouse bone marrow, representing subpopulations of putative stromal cell types, were examined for the expression of osteoblastic properties. The effects of dexamethasone and specific inhibitors on alkaline phosphatase activity, cAMP response to bone-seeking hormones, and the ability to mineralize extracellular matrix in vitro as well as collagen typing were used as osteoblastic markers. We found that all stromal cell types examined posses some osteoblastic features but differ in the degree of expression. The data provide support to the hypothesis of a common stem cell for marrow stromal cells.

Original language	English
Pages (from-to)	202-207
Number of pages	6
Journal	Calcified Tissue International
Volume	49
Issue number	3
DOIs	https://doi.org/10.1007/BF02556119
State	Published - May 1991

Keywords

Marrow stromal cells
Osteoblast
Osteoblastic markers
Stromal cell lines

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/BF02556119

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title = "Subpopulations of marrow stromal cells share a variety of osteoblastic markers",

abstract = "A series of stromal cell lines derived from mouse bone marrow, representing subpopulations of putative stromal cell types, were examined for the expression of osteoblastic properties. The effects of dexamethasone and specific inhibitors on alkaline phosphatase activity, cAMP response to bone-seeking hormones, and the ability to mineralize extracellular matrix in vitro as well as collagen typing were used as osteoblastic markers. We found that all stromal cell types examined posses some osteoblastic features but differ in the degree of expression. The data provide support to the hypothesis of a common stem cell for marrow stromal cells.",

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AU - Zipori, Dov

AU - Wientroub, Shlomo

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N2 - A series of stromal cell lines derived from mouse bone marrow, representing subpopulations of putative stromal cell types, were examined for the expression of osteoblastic properties. The effects of dexamethasone and specific inhibitors on alkaline phosphatase activity, cAMP response to bone-seeking hormones, and the ability to mineralize extracellular matrix in vitro as well as collagen typing were used as osteoblastic markers. We found that all stromal cell types examined posses some osteoblastic features but differ in the degree of expression. The data provide support to the hypothesis of a common stem cell for marrow stromal cells.

AB - A series of stromal cell lines derived from mouse bone marrow, representing subpopulations of putative stromal cell types, were examined for the expression of osteoblastic properties. The effects of dexamethasone and specific inhibitors on alkaline phosphatase activity, cAMP response to bone-seeking hormones, and the ability to mineralize extracellular matrix in vitro as well as collagen typing were used as osteoblastic markers. We found that all stromal cell types examined posses some osteoblastic features but differ in the degree of expression. The data provide support to the hypothesis of a common stem cell for marrow stromal cells.

KW - Marrow stromal cells

KW - Osteoblast

KW - Osteoblastic markers

KW - Stromal cell lines

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ER -

Subpopulations of marrow stromal cells share a variety of osteoblastic markers

Abstract

Keywords

UN SDGs

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