TY - JOUR
T1 - Subjects' dissimilarity in the analysis of laser-tissue dose-response experiments
T2 - A potential cause for puzzling results
AU - Gannot, I.
AU - Langus, A.
AU - Fuchs, C.
N1 - Funding Information:
The study renalyses the raw data from the spectral ED50s experiment [5] performed by the US Army Medical Research Detachment Walter Reed Army Institute of Research (USAMRD-WRAIR). The USAMRD-WRAIR found that their experiment shows a puzzling dependency of the ED50 on the laser wavelength. This issue has remained unresolved for the last decade.
PY - 2002
Y1 - 2002
N2 - The in vivo dose-response laser-tissue experiment is usually performed on several subjects, each exposed several times at different tissue sites. The collected data are then unified into a single statistical batch and analysed under the tacit assumption that the tolerances of all the subjects are similar. However, if this assumption is incorrect the data unification may lead to very biased results. This study reanalyses a raw data set measured by the US Army Medical Research Detachment Walter Reed Army Institute of Research (USAMRD-WRAIR), which was used to study the influence of the laser wavelength on the energy threshold of retinal injury. The USAMRD-WRAIR report reveals a significant variation of threshold with small changes in wavelength. Despite an extensive study, performed by the USAMRD-WRAIR researchers, which included possible lasers variations, many aspects of experimental technique and biological absorption properties of the eye, a cause for the threshold variation was not found. Our current results suggest that unaccounted specimen's dissimilarity might be the cause for this unclear threshold variations.
AB - The in vivo dose-response laser-tissue experiment is usually performed on several subjects, each exposed several times at different tissue sites. The collected data are then unified into a single statistical batch and analysed under the tacit assumption that the tolerances of all the subjects are similar. However, if this assumption is incorrect the data unification may lead to very biased results. This study reanalyses a raw data set measured by the US Army Medical Research Detachment Walter Reed Army Institute of Research (USAMRD-WRAIR), which was used to study the influence of the laser wavelength on the energy threshold of retinal injury. The USAMRD-WRAIR report reveals a significant variation of threshold with small changes in wavelength. Despite an extensive study, performed by the USAMRD-WRAIR researchers, which included possible lasers variations, many aspects of experimental technique and biological absorption properties of the eye, a cause for the threshold variation was not found. Our current results suggest that unaccounted specimen's dissimilarity might be the cause for this unclear threshold variations.
KW - Laser tissue interactions
KW - Specimen's dissimilarity
KW - Stochastic characteristics
UR - http://www.scopus.com/inward/record.url?scp=0036174073&partnerID=8YFLogxK
U2 - 10.1007/s10103-002-8261-x
DO - 10.1007/s10103-002-8261-x
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AN - SCOPUS:0036174073
SN - 0268-8921
VL - 17
SP - 13
EP - 18
JO - Lasers in Medical Science
JF - Lasers in Medical Science
IS - 1
ER -