TY - JOUR
T1 - Subfertility, use of fertility treatments and BRCA mutation status and the risk of ovarian cancer
AU - for the National Israel Ovarian Cancer Study Group
AU - Lerner-Geva, Liat
AU - Chetrit, Angela
AU - Farhi, Adel
AU - Lubin, Flora
AU - Sadezki, Siegal
AU - Anderman, Shmuel
AU - Altaras, Marco
AU - Anteby, Shaul
AU - Atad, Jack
AU - Avni, Amiram
AU - Bar-Am, Amiran
AU - Beck, Dan
AU - Beller, Uzi
AU - Ben-Baruch, Gilad
AU - Ben-David, Yehuda
AU - Biran, Haim
AU - Ami, Moshe Ben
AU - Cohan, Shulamit
AU - Dgani, Ram
AU - Fishler, Yehudit
AU - Fishman, Ami
AU - Friedman, Eitan
AU - Gemer, Ofer
AU - Gershoni, Ruth
AU - Gottlieb, Walter
AU - Halperin, Reuvit
AU - Hirsh-Yechezkel, Galit
AU - Idelman, David
AU - Katan, Rafael
AU - Kopilovic, Yuri
AU - Lahad, Efrat
AU - Geva, Liat Lerner
AU - Levavi, Hanoch
AU - Levit, Albert
AU - Levy, Tally
AU - Lifschiz-Mercer, Beatriz
AU - Liviatan, Zohar
AU - Markovich, Jacob
AU - Menzcer, Joseph
AU - Modan, Baruch
AU - Nitzan, Hedva
AU - Oettinger, Moshe
AU - Peretz, Tamar
AU - Piura, Benjamin
AU - Rizel, Shulamit
AU - Sadetzki, Siegal
AU - Shani, Adi
AU - Schneider, David
AU - Shtark, Michael
AU - Shteiner, Mariana
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/7
Y1 - 2022/7
N2 - Purpose: The objective of the study is to evaluate the possible association between history of subfertility, fertility treatments, BRCA mutations and the risk of ovarian cancer. Methods: This Israeli National Case–Control study included 1269 consecutive ovarian cancer cases and 2111 individually matched healthy controls. All participants were interviewed and molecular analysis of BRCA mutations were performed to 896 cases. The main outcome measure was reported history of subfertility and exposure to fertility treatments. Results: The rate of reported subfertility was 15.1% and 14.3% in ovarian cancer cases and controls, respectively. However, subfertility was more prevalent in cases with borderline ovarian cancer (but not for invasive ovarian cancer cases) than controls. Multivariate conditional logistic regression revealed that the risk of borderline ovarian cancer was elevated in both women treated for subfertility and those that were not treated for subfertility, (OR = 1.74; 95% CI 0.9–3.36 and OR = 1.79; 95% CI 0.98–3.26, respectively). In non-carriers of BRCA1/2 mutations, fertility treatments were associated with a decreased risk of invasive ovarian cancer while a significant increased risk of borderline ovarian cancer was observed (OR = 2.92, 95%CI 1.67–5.10). Conclusions: Reported subfertility and exposure to fertility treatments were associated with borderline but not with invasive ovarian tumors. This association was more prominent in women who are non-carriers of a BRCA mutation.
AB - Purpose: The objective of the study is to evaluate the possible association between history of subfertility, fertility treatments, BRCA mutations and the risk of ovarian cancer. Methods: This Israeli National Case–Control study included 1269 consecutive ovarian cancer cases and 2111 individually matched healthy controls. All participants were interviewed and molecular analysis of BRCA mutations were performed to 896 cases. The main outcome measure was reported history of subfertility and exposure to fertility treatments. Results: The rate of reported subfertility was 15.1% and 14.3% in ovarian cancer cases and controls, respectively. However, subfertility was more prevalent in cases with borderline ovarian cancer (but not for invasive ovarian cancer cases) than controls. Multivariate conditional logistic regression revealed that the risk of borderline ovarian cancer was elevated in both women treated for subfertility and those that were not treated for subfertility, (OR = 1.74; 95% CI 0.9–3.36 and OR = 1.79; 95% CI 0.98–3.26, respectively). In non-carriers of BRCA1/2 mutations, fertility treatments were associated with a decreased risk of invasive ovarian cancer while a significant increased risk of borderline ovarian cancer was observed (OR = 2.92, 95%CI 1.67–5.10). Conclusions: Reported subfertility and exposure to fertility treatments were associated with borderline but not with invasive ovarian tumors. This association was more prominent in women who are non-carriers of a BRCA mutation.
KW - BRCA mutations
KW - Fertility treatments
KW - Ovarian cancer
KW - Subfertility
UR - http://www.scopus.com/inward/record.url?scp=85134589216&partnerID=8YFLogxK
U2 - 10.1007/s00404-021-06355-6
DO - 10.1007/s00404-021-06355-6
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C2 - 35039881
AN - SCOPUS:85134589216
SN - 0932-0067
VL - 306
SP - 209
EP - 217
JO - Archives of Gynecology and Obstetrics
JF - Archives of Gynecology and Obstetrics
IS - 1
ER -