Subcutaneous ustekinumab for the treatment of anti-TNF resistant Crohn's disease-The McGill experience

U. Kopylov, W. Afif, A. Cohen, A. Bitton, G. Wild, T. Bessissow, J. Wyse, T. Al-Taweel, A. Szilagyi, E. Seidman

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Ustekinumab is a fully human IgG1κ monoclonal antibody that blocks the biologic activity of interleukin-12/23. Ustekinumab is approved for treatment of plaque psoriasis and has been shown to be effective for induction and maintenance of clinical response in anti-TNF resistant Crohn's disease (CD). The aim of the study was to describe the real-life experience with open-label use of ustekinumab in anti-TNF resistant CD patients. Methods: A retrospective observational open-label study. Clinical response was defined by physician's global assessment combined with decision to continue therapy. The clinical response was evaluated at 3, 6, 12. months and last follow-up. Results: Thirty-eight patients were included in the study. Initial clinical response was achieved in 28/38 (73.7%) of the patients. Among the initial responders, 80% with follow-up data maintained their response for 6. months. At 12. months of follow-up, 88.9% of patients responding at 6. months maintained their response. At the last follow-up (7.9. ±. 5.2 mo) 27/38 (71%) of the patients were responding, and 73.3% were able to discontinue corticosteroids. Dose escalation was required in 47.7% of the patients and was successful in 61.1% of them. Summary: In this real-life cohort of severe anti-TNF resistant CD, an initial clinical response to subcutaneous ustekinumab was observed in 73.7% of the patients. The initial response was successfully maintained in the majority of patients for up to 12. months. Subcutaneous ustekinumab is an effective therapeutic option in this challenging patient cohort. The optimal dosing and injection schedule remain to be established in future studies.

Original languageEnglish
Pages (from-to)1516-1522
Number of pages7
JournalJournal of Crohn's and Colitis
Volume8
Issue number11
DOIs
StatePublished - 2014
Externally publishedYes

Keywords

  • Biologics
  • Crohn's disease
  • TNF-alpha inhibitors
  • Ustekinumab

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