Subacute sclerosing panencephalitis: Measles virus matrix protein nucleic acid sequences detected by in situ hybridization

P. Shapshak; W. W. Tourtellotte; S. Nakamura; M. C. Graves; M. Darvish; D. Hoffman; M. J. Walsh; G. C. Fareed; P. Schmid; C. Heinzmann; K. Sidhu; E. Bedows; S. Rozenblatt; K. Berry; S. Hawkins

doi:10.1212/wnl.35.11.1605

Subacute sclerosing panencephalitis: Measles virus matrix protein nucleic acid sequences detected by in situ hybridization

P. Shapshak, W. W. Tourtellotte, S. Nakamura, M. C. Graves, M. Darvish, D. Hoffman, M. J. Walsh, G. C. Fareed, P. Schmid, C. Heinzmann, K. Sidhu, E. Bedows, S. Rozenblatt, K. Berry, S. Hawkins

Research output: Contribution to journal › Article › peer-review

Abstract

Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypep-tides of measles virus except the matrix (M) protein. Using cloned (³H)-labeled complementary DNA probes for in situ hybridization, we found the IM protein and nucleocapsid (NP) protein nucleotide sequences in glial cells and neurons of cryostat sections from two SSPE brains. In one SSPE brain, M protein was lacking, but the other measles polypeptides were present. IgG and IgM antibodies eluted from that brain lacked antibodies to M protein, but antibodies to other measles polypeptides were present. In SSPE brain, the viral M-protein defect is not a deletion of the M gene, but rather a block in gene expression.

Original language	English
Pages (from-to)	1605-1609
Number of pages	5
Journal	Neurology
Volume	35
Issue number	11
DOIs	https://doi.org/10.1212/wnl.35.11.1605
State	Published - Nov 1985
Externally published	Yes

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Shapshak, P., Tourtellotte, W. W., Nakamura, S., Graves, M. C., Darvish, M., Hoffman, D., Walsh, M. J., Fareed, G. C., Schmid, P., Heinzmann, C., Sidhu, K., Bedows, E., Rozenblatt, S., Berry, K., & Hawkins, S. (1985). Subacute sclerosing panencephalitis: Measles virus matrix protein nucleic acid sequences detected by in situ hybridization. Neurology, 35(11), 1605-1609. https://doi.org/10.1212/wnl.35.11.1605

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title = "Subacute sclerosing panencephalitis: Measles virus matrix protein nucleic acid sequences detected by in situ hybridization",

abstract = "Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypep-tides of measles virus except the matrix (M) protein. Using cloned (3H)-labeled complementary DNA probes for in situ hybridization, we found the IM protein and nucleocapsid (NP) protein nucleotide sequences in glial cells and neurons of cryostat sections from two SSPE brains. In one SSPE brain, M protein was lacking, but the other measles polypeptides were present. IgG and IgM antibodies eluted from that brain lacked antibodies to M protein, but antibodies to other measles polypeptides were present. In SSPE brain, the viral M-protein defect is not a deletion of the M gene, but rather a block in gene expression.",

author = "P. Shapshak and Tourtellotte, {W. W.} and S. Nakamura and Graves, {M. C.} and M. Darvish and D. Hoffman and Walsh, {M. J.} and Fareed, {G. C.} and P. Schmid and C. Heinzmann and K. Sidhu and E. Bedows and S. Rozenblatt and K. Berry and S. Hawkins",

year = "1985",

month = nov,

doi = "10.1212/wnl.35.11.1605",

language = "אנגלית",

volume = "35",

pages = "1605--1609",

journal = "Neurology",

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publisher = "Lippincott Williams and Wilkins Ltd.",

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Shapshak, P, Tourtellotte, WW, Nakamura, S, Graves, MC, Darvish, M, Hoffman, D, Walsh, MJ, Fareed, GC, Schmid, P, Heinzmann, C, Sidhu, K, Bedows, E, Rozenblatt, S, Berry, K & Hawkins, S 1985, 'Subacute sclerosing panencephalitis: Measles virus matrix protein nucleic acid sequences detected by in situ hybridization', Neurology, vol. 35, no. 11, pp. 1605-1609. https://doi.org/10.1212/wnl.35.11.1605

TY - JOUR

T1 - Subacute sclerosing panencephalitis

T2 - Measles virus matrix protein nucleic acid sequences detected by in situ hybridization

AU - Shapshak, P.

AU - Tourtellotte, W. W.

AU - Nakamura, S.

AU - Graves, M. C.

AU - Darvish, M.

AU - Hoffman, D.

AU - Walsh, M. J.

AU - Fareed, G. C.

AU - Schmid, P.

AU - Heinzmann, C.

AU - Sidhu, K.

AU - Bedows, E.

AU - Rozenblatt, S.

AU - Berry, K.

AU - Hawkins, S.

PY - 1985/11

Y1 - 1985/11

N2 - Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypep-tides of measles virus except the matrix (M) protein. Using cloned (3H)-labeled complementary DNA probes for in situ hybridization, we found the IM protein and nucleocapsid (NP) protein nucleotide sequences in glial cells and neurons of cryostat sections from two SSPE brains. In one SSPE brain, M protein was lacking, but the other measles polypeptides were present. IgG and IgM antibodies eluted from that brain lacked antibodies to M protein, but antibodies to other measles polypeptides were present. In SSPE brain, the viral M-protein defect is not a deletion of the M gene, but rather a block in gene expression.

AB - Subacute sclerosing panencephalitis (SSPE) is characterized by a hyperimmune state toward the polypep-tides of measles virus except the matrix (M) protein. Using cloned (3H)-labeled complementary DNA probes for in situ hybridization, we found the IM protein and nucleocapsid (NP) protein nucleotide sequences in glial cells and neurons of cryostat sections from two SSPE brains. In one SSPE brain, M protein was lacking, but the other measles polypeptides were present. IgG and IgM antibodies eluted from that brain lacked antibodies to M protein, but antibodies to other measles polypeptides were present. In SSPE brain, the viral M-protein defect is not a deletion of the M gene, but rather a block in gene expression.

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DO - 10.1212/wnl.35.11.1605

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AN - SCOPUS:0022213426

VL - 35

SP - 1605

EP - 1609

JO - Neurology

JF - Neurology

SN - 0028-3878

IS - 11

ER -

Subacute sclerosing panencephalitis: Measles virus matrix protein nucleic acid sequences detected by in situ hybridization

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