Subacute painful lumbosacral polyradiculoneuropathy in immunocompromised patients

Israel Steiner*, Oren Cohen, Ronen R. Leker, Bina Rubinovitch, Rachel Handsher, Sharon Hassin-Baer, Donald H. Gilden, Menachem Sadeh

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

7 Scopus citations

Abstract

The syndrome of inflammatory subacute lumbosacral polyradiculoneuropathy (SLP) has been reported in acquired immunodeficiency syndrome (AIDS) patients in association with cytomegalovirus infection and is only partially amenable to anti-viral therapy. We report three cases of relatively benign inflammatory painful SLP in two non-AIDS, immunosuppressed patients and one who HIV-seroconversed at the time of clinical presentation. SLP developed: (1) in association with HIV seroconversion; (2) during ECHO virus infection in a patient with common variable immune deficiency; and (3) after a severe systemic infection that induced transient immunosuppression due to Epstein- Barr virus reactivation. This report expands the spectrum of viruses associated with acute and subacute lumbosacral polyradiculoneuropathy and may shed light on its possible pathogenesis.

Original languageEnglish
Pages (from-to)91-93
Number of pages3
JournalJournal of the Neurological Sciences
Volume162
Issue number1
DOIs
StatePublished - 1 Jan 1999
Externally publishedYes

Funding

FundersFunder number
Hilda Katz Blaustein Fund for Neurological Research
National Institutes of HealthNS 32623
National Institute on AgingR37AG006127
U.S. Public Health Service

    Keywords

    • Immune deficiency
    • Immunosuppression
    • Peripheral neuropathy
    • Viral infection

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