Subacute painful lumbosacral polyradiculoneuropathy in immunocompromised patients

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The syndrome of inflammatory subacute lumbosacral polyradiculoneuropathy (SLP) has been reported in acquired immunodeficiency syndrome (AIDS) patients in association with cytomegalovirus infection and is only partially amenable to anti-viral therapy. We report three cases of relatively benign inflammatory painful SLP in two non-AIDS, immunosuppressed patients and one who HIV-seroconversed at the time of clinical presentation. SLP developed: (1) in association with HIV seroconversion; (2) during ECHO virus infection in a patient with common variable immune deficiency; and (3) after a severe systemic infection that induced transient immunosuppression due to Epstein- Barr virus reactivation. This report expands the spectrum of viruses associated with acute and subacute lumbosacral polyradiculoneuropathy and may shed light on its possible pathogenesis.

Original languageEnglish
Pages (from-to)91-93
Number of pages3
JournalJournal of the Neurological Sciences
Issue number1
StatePublished - 1 Jan 1999
Externally publishedYes


  • Immune deficiency
  • Immunosuppression
  • Peripheral neuropathy
  • Viral infection


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