TY - JOUR
T1 - Subacute painful lumbosacral polyradiculoneuropathy in immunocompromised patients
N1 - Funding Information:
Supported in part by Public Health Service Grants from the National Institutes of Health (AG 06127 and NS 32623), and by the Hilda Katz Blaustein Fund for Neurological Research. We thank Lisa Schneck for editorial review.
PY - 1999/1/1
Y1 - 1999/1/1
N2 - The syndrome of inflammatory subacute lumbosacral polyradiculoneuropathy (SLP) has been reported in acquired immunodeficiency syndrome (AIDS) patients in association with cytomegalovirus infection and is only partially amenable to anti-viral therapy. We report three cases of relatively benign inflammatory painful SLP in two non-AIDS, immunosuppressed patients and one who HIV-seroconversed at the time of clinical presentation. SLP developed: (1) in association with HIV seroconversion; (2) during ECHO virus infection in a patient with common variable immune deficiency; and (3) after a severe systemic infection that induced transient immunosuppression due to Epstein- Barr virus reactivation. This report expands the spectrum of viruses associated with acute and subacute lumbosacral polyradiculoneuropathy and may shed light on its possible pathogenesis.
AB - The syndrome of inflammatory subacute lumbosacral polyradiculoneuropathy (SLP) has been reported in acquired immunodeficiency syndrome (AIDS) patients in association with cytomegalovirus infection and is only partially amenable to anti-viral therapy. We report three cases of relatively benign inflammatory painful SLP in two non-AIDS, immunosuppressed patients and one who HIV-seroconversed at the time of clinical presentation. SLP developed: (1) in association with HIV seroconversion; (2) during ECHO virus infection in a patient with common variable immune deficiency; and (3) after a severe systemic infection that induced transient immunosuppression due to Epstein- Barr virus reactivation. This report expands the spectrum of viruses associated with acute and subacute lumbosacral polyradiculoneuropathy and may shed light on its possible pathogenesis.
KW - Immune deficiency
KW - Immunosuppression
KW - Peripheral neuropathy
KW - Viral infection
UR - http://www.scopus.com/inward/record.url?scp=0032921565&partnerID=8YFLogxK
U2 - 10.1016/S0022-510X(98)00282-2
DO - 10.1016/S0022-510X(98)00282-2
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AN - SCOPUS:0032921565
SN - 0022-510X
VL - 162
SP - 91
EP - 93
JO - Journal of the Neurological Sciences
JF - Journal of the Neurological Sciences
IS - 1
ER -
