TY - JOUR
T1 - Subacute central nervous system degeneration in a child
T2 - An unusual manifestation of ifosfamide intoxication
AU - Shuper, Avinoam
AU - Stein, Jeremiah
AU - Goshen, Jacob
AU - Kornreich, Liora
AU - Yaniv, Izhak
AU - Cohen, Ian J.
AU - Tiqva, Petah
PY - 2000/7
Y1 - 2000/7
N2 - A 5-year-old child with desmoplastic small round-cell tumor was treated with a protocol of very-high-dose, short-term chemotherapy, containing HD-CAV (cyclophosphamide, doxorubicin, vincristine, and mesna), ifosfamide, and etoposide. Two days after the initiation of ifosfamide, he exhibited new- onset lethal encephalopathy manifested by subacutely progressive cerebellar and then temporal and fontocortical degeneration leading to a vegetative state and eventually to death. A full work-up, including brain biopsy, was negative, excluding infections and metabolic or vascular causes. Ifosfamide is known to be capable of causing acute encephalopathy that can be severe but is generally reversible. This child showed a very atypical progressive, lethal course of ifosfamide toxicity. The possibility of this complication should be considered when high-dose ifosfamide treatment is planned for children.
AB - A 5-year-old child with desmoplastic small round-cell tumor was treated with a protocol of very-high-dose, short-term chemotherapy, containing HD-CAV (cyclophosphamide, doxorubicin, vincristine, and mesna), ifosfamide, and etoposide. Two days after the initiation of ifosfamide, he exhibited new- onset lethal encephalopathy manifested by subacutely progressive cerebellar and then temporal and fontocortical degeneration leading to a vegetative state and eventually to death. A full work-up, including brain biopsy, was negative, excluding infections and metabolic or vascular causes. Ifosfamide is known to be capable of causing acute encephalopathy that can be severe but is generally reversible. This child showed a very atypical progressive, lethal course of ifosfamide toxicity. The possibility of this complication should be considered when high-dose ifosfamide treatment is planned for children.
UR - http://www.scopus.com/inward/record.url?scp=0033943256&partnerID=8YFLogxK
U2 - 10.1177/088307380001500711
DO - 10.1177/088307380001500711
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AN - SCOPUS:0033943256
SN - 0883-0738
VL - 15
SP - 481
EP - 483
JO - Journal of Child Neurology
JF - Journal of Child Neurology
IS - 7
ER -