TY - JOUR
T1 - Stuttering and Incident Type 2 Diabetes
T2 - A Population-Based Study of 2.2 Million Adolescents
AU - Tsur, Avishai M.
AU - Hershkovich, Shir
AU - Zucker, Inbar
AU - Lutski, Miri
AU - Pinhas-Hamiel, Orit
AU - Vivante, Asaf
AU - Fischman, Maya
AU - Amir, Ofer
AU - Rotchild, Jacob
AU - Gerstein, Hertzel C.
AU - Cukierman-Yaffe, Tali
AU - Friedensohn, Limor
AU - Mosenzon, Ofri
AU - Derazne, Estela
AU - Tzur, Dorit
AU - Tirosh, Amir
AU - Afek, Arnon
AU - Raz, Itamar
AU - Twig, Gilad
N1 - Publisher Copyright:
© 2021 The Author(s) 2021. Published by Oxford University Press on behalf of the Endocrine Society. All rights reserved. For permissions, please e-mail: [email protected].
PY - 2021/4/1
Y1 - 2021/4/1
N2 - Purpose: To investigate the association between stuttering in adolescence and incident type 2 diabetes in young adulthood. Methods: This nationwide population-based study included 2 193 855 adolescents of age 16 to 20 years who were assessed for military service between 1980 and 2013. Diagnoses of stuttering in adolescence were confirmed by a speech-language pathologist. Diabetes status for each individual as of December 31, 2016, was determined by linkage to the Israeli National Diabetes Registry. Relationships were analyzed using regression models adjusted for socioeconomic variables, cognitive performance, coexisting morbidities, and adolescent body mass index. Results: Analysis was stratified by sex (Pinteraction = 0.035). Of the 4443 (0.4%) adolescent men with stuttering, 162 (3.7%) developed type 2 diabetes, compared with 25 678 (2.1%) men without stuttering (adjusted odds ratio [OR] 1.3; 95% CI, 1.1-1.6). This relationship persisted when unaffected brothers of men with stuttering were used as the reference group (adjusted OR = 1.5; 95% CI, 1.01-2.2), or when the analysis included only adolescents with unimpaired health at baseline (adjusted OR = 1.4; 95% CI, 1.1-1.7). The association was stronger in later birth cohorts, with an adjusted OR of 2.4 (1.4-4.1) for cases of type 2 diabetes before age 40. Of the 503 (0.1%) adolescent women with stuttering 7 (1.4%) developed type 2 diabetes, compared with 10 139 (1.1%) women without stuttering (OR = 2.03; 95% CI, 0.48-2.20). Conclusions: Adolescent stuttering is associated with an increased risk for early-onset type 2 diabetes among men.
AB - Purpose: To investigate the association between stuttering in adolescence and incident type 2 diabetes in young adulthood. Methods: This nationwide population-based study included 2 193 855 adolescents of age 16 to 20 years who were assessed for military service between 1980 and 2013. Diagnoses of stuttering in adolescence were confirmed by a speech-language pathologist. Diabetes status for each individual as of December 31, 2016, was determined by linkage to the Israeli National Diabetes Registry. Relationships were analyzed using regression models adjusted for socioeconomic variables, cognitive performance, coexisting morbidities, and adolescent body mass index. Results: Analysis was stratified by sex (Pinteraction = 0.035). Of the 4443 (0.4%) adolescent men with stuttering, 162 (3.7%) developed type 2 diabetes, compared with 25 678 (2.1%) men without stuttering (adjusted odds ratio [OR] 1.3; 95% CI, 1.1-1.6). This relationship persisted when unaffected brothers of men with stuttering were used as the reference group (adjusted OR = 1.5; 95% CI, 1.01-2.2), or when the analysis included only adolescents with unimpaired health at baseline (adjusted OR = 1.4; 95% CI, 1.1-1.7). The association was stronger in later birth cohorts, with an adjusted OR of 2.4 (1.4-4.1) for cases of type 2 diabetes before age 40. Of the 503 (0.1%) adolescent women with stuttering 7 (1.4%) developed type 2 diabetes, compared with 10 139 (1.1%) women without stuttering (OR = 2.03; 95% CI, 0.48-2.20). Conclusions: Adolescent stuttering is associated with an increased risk for early-onset type 2 diabetes among men.
KW - adolescent
KW - diabetes mellitus
KW - stuttering
KW - type 2
UR - http://www.scopus.com/inward/record.url?scp=85103606596&partnerID=8YFLogxK
U2 - 10.1210/clinem/dgaa988
DO - 10.1210/clinem/dgaa988
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C2 - 33449080
AN - SCOPUS:85103606596
SN - 0021-972X
VL - 106
SP - 978
EP - 987
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 4
ER -