TY - JOUR
T1 - Studies on opacity factor production by pharyngeal isolates of group A streptococci
AU - Bergner Rabinowitz, S.
AU - Ofek, I.
PY - 1976
Y1 - 1976
N2 - Production of opacity factor (OF) by 841 pharyngeal isolates of group A streptococci from schoolchildren was studied along with T and M typing of the streptococcal strains. The majority (89%) of M typable strains were OF negative in contrast to M nontypable isolates, 45% of which were OF positive. There was no apparent relation between the production of OF by the M nontypable isolates and the type of infection (symptomatic vs. asymptomatic), degree of positivity of initial culture, antistreptolysin O response and failure to eradicate the organisms by treatment with antibiotics. However, seasonal shifts in the prevalence of M nontypable OF positive strains provided evidence of change in streptococcal ecology; such as shift would not have been detected by T typing alone. Thus, OF production is an additional epidemiologic marker that is helpful in differentiating M nontypable group A strains that bear common T antigens.
AB - Production of opacity factor (OF) by 841 pharyngeal isolates of group A streptococci from schoolchildren was studied along with T and M typing of the streptococcal strains. The majority (89%) of M typable strains were OF negative in contrast to M nontypable isolates, 45% of which were OF positive. There was no apparent relation between the production of OF by the M nontypable isolates and the type of infection (symptomatic vs. asymptomatic), degree of positivity of initial culture, antistreptolysin O response and failure to eradicate the organisms by treatment with antibiotics. However, seasonal shifts in the prevalence of M nontypable OF positive strains provided evidence of change in streptococcal ecology; such as shift would not have been detected by T typing alone. Thus, OF production is an additional epidemiologic marker that is helpful in differentiating M nontypable group A strains that bear common T antigens.
UR - http://www.scopus.com/inward/record.url?scp=0017172876&partnerID=8YFLogxK
U2 - 10.1093/infdis/134.2.189
DO - 10.1093/infdis/134.2.189
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C2 - 972266
AN - SCOPUS:0017172876
SN - 0022-1899
VL - 134
SP - 189
EP - 192
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 2
ER -