Studies of peptidergic input to the lateral spinal nucleus

Kenneth D. Cliffer, Gideon Urca, Robert P. Elde, Glenn J. Giesler*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Lesions were made to interrupt potential sources of peptidergic input to the lateral spinal nucleus (LSn) in rats. Rhizotomies and spinal transections, as well as lesions of the lateral funiculus, failed to reduce immunohistochemical staining for substance P, dynorphin1-8, Met-enkephalin, somatostatin and FMRF-amide in the LSn at lumbar levels. Thus, all examined peptidergic afferent input to the LSn appears to originate locally within the spinal cord.

Original languageEnglish
Pages (from-to)356-360
Number of pages5
JournalBrain Research
Volume460
Issue number2
DOIs
StatePublished - 20 Sep 1988
Externally publishedYes

Funding

FundersFunder number
National Institute on Drug AbuseR01DA002148

    Keywords

    • Dynorphin
    • Enkephalin
    • Lateral spinal nucleus
    • Peptide
    • Somatostatin
    • Substance P

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