Structured cognitive-motor dual task training compared to single mobility training in persons with multiple sclerosis, a multicenter RCT

Renee Veldkamp*, Ilse Baert, Alon Kalron, Andrea Tacchino, Mieke D’hooge, Ellen Vanzeir, Fanny Van Geel, Joke Raats, Mieke Goetschalckx, Giampaolo Brichetto, Nov Shalmoni, Peter Hellinckx, Natasja De Weerdt, Dorien De Wilde, Peter Feys

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

36 Scopus citations

Abstract

The aim was to compare the effectiveness of dual-task training (DTT) compared to single mobility training (SMT) on dual-task walking, mobility and cognition, in persons with Multiple Sclerosis (pwMS). Forty pwMS were randomly assigned to the DTT or SMT groups. The DTT-group performed dual-task exercises using an interactive tablet-based application, while the SMT-group received conventional walking and balance exercises. Both interventions were supervised and identical in weeks (8) and sessions (20). Nine cognitive-motor dual-task conditions were assessed at baseline, after intervention and at 4-weeks follow-up (FU). The dual-task cost (DTC), percentage change of dual-task performance compared to single-task performance, was the primary outcome. Mobility and cognition were secondarily assessed. Mixed model analyses were done with group, time and the interaction between group and time as fixed factors and participants as random factors. Significant time by group interactions were found for the digit-span walk and subtraction walk dual-task conditions, with a reduction in DTC (gait speed) for the DTT maintained at FU. Further, absolute dual-task gait speed during walking over obstacles only improved after the DTT. Significant improvements were found for both groups in various motor and cognitive measures. However, the DTT led to better dual-task walking compared to the SMT.

Original languageEnglish
Article number2177
JournalJournal of Clinical Medicine
Volume8
Issue number12
DOIs
StatePublished - Dec 2019

Keywords

  • Balance
  • Cognition
  • Cognitive motor interference
  • Dual task
  • Gait
  • Multiple sclerosis

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