Structure, molecular genetics, and evolution of vacuolar H+-ATPases

Nathan Nelson*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

112 Scopus citations


Proton-ATPases can be divided into three classes denoted as P-, F-, and V-ATPases. The P-ATPases are evolutionarily distinct from the F- and V-type ATPases which have been shown to be related, probably evolved from a common ancestral enzyme. Like F-ATPases, V-ATPases are composed of two distinct structures: a catalytic sector that is hydrophilic in nature and a hydrophobic membrane sector which functions in proton conduction. Recent studies on the molecular biology of vacuolar H+-ATPases revealed surprising findings about the evolution of pronon pumps as well as important clues for the evolution of eukaryotic cells.

Original languageEnglish
Pages (from-to)553-571
Number of pages19
JournalJournal of Bioenergetics and Biomembranes
Issue number5
StatePublished - Oct 1989
Externally publishedYes


  • Proton-ATPase
  • eukaryotic cells
  • evolution
  • molecular biology
  • structure and function
  • transport
  • vacuolar system


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