Structure-guided probing of the leukotriene C₄ binding site in human multidrug resistance protein 1 (MRP1; ABCC1)

Medicine & Life Sciences

• Amino Acids 4%
• Anions 7%
• ATP Binding Cassette Transporter, Subfamily B, Member 1 71%
• Binding Sites 50%
• Cattle 5%
• Conjugated (USP) Estrogens 8%
• Cryoelectron Microscopy 8%
• Drug Resistance 5%
• Estradiol 5%
• estrone sulfate 9%
• Fatty Acids 5%
• Glucuronides 7%
• Glutathione 5%
• Leukotriene C4 86%
• Lipids 4%
• multidrug resistance-associated protein 1 91%
• Multiple Drug Resistance 6%
• Mutation 7%
• Neoplasms 2%
• Pharmaceutical Preparations 2%
• Steroids 4%

Chemistry

• Acid 2%
• Binding Site 45%
• Drug 3%
• Estradiol 8%
• Estrogen 7%
• Estrone 3-Sulfate 12%
• Fatty Acid 5%
• Glutathione 6%
• Leukotriene 9%
• Leukotriene C4 100%
• Lipid 4%
• Mutation 12%
• Organic Anion 9%
• Protein 26%
• Resistance 40%
• Steroid 6%
• Substitution Reaction 9%