Structure and Conformation of Heterocycles. 11. cis-and trans-2, 3-Difluoro-1, 4-dioxane. Gauche and Anomeric Effects of Fluorine

Benzion Fuchs, Aviyakar Ellencweig

Research output: Contribution to journalArticlepeer-review

Abstract

The title compounds were synthesized along with trans-2-fluoro-3-chloro-1, 4-dioxane and conformationally analyzed using 1H, 19F, and 13C NMR spectroscopic methods. The trans compound was concluded to occur in better than 96% as diaxial conformers. This is discussed in terms of the “anomeric effect” and “gauche effect” of fluorine.

Original languageEnglish
Pages (from-to)2274-2277
Number of pages4
JournalJournal of Organic Chemistry
Volume44
Issue number13
DOIs
StatePublished - 1 Feb 1979

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