Structure and activity of the translocated c-myc in mouse plasmacytoma XRPC-24

B. Moav, M. Horowitz, J. B. Cohen, G. Rechavi, E. Eliyahu, M. Oren, D. Givol*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In the mouse plasmacytoma XRPC-24 both c-mos and c-myc are rearranged. We cloned the rearranged c-myc and found that it was translocated to the immunoglobulin Cα locus. The breakpoint is at the end of exon 1 in c-myc and approximately 0.5 kb upstream from exon 1 of Cα. The cloned translocated c-myc linked to a strong transcriptional promoter can efficiently transform rat embryo fibroblasts when co-transfected with the activated Ha-ras. The transformed cells are tumorigenic in syngeneic rats.

Original languageEnglish
Pages (from-to)297-300
Number of pages4
JournalGene
Volume48
Issue number2-3
DOIs
StatePublished - 1986
Externally publishedYes

Keywords

  • Recombinant DNA
  • cell transformation
  • genome rearrangement
  • oncogenes

Fingerprint

Dive into the research topics of 'Structure and activity of the translocated c-myc in mouse plasmacytoma XRPC-24'. Together they form a unique fingerprint.

Cite this