Abstract
In the mouse plasmacytoma XRPC-24 both c-mos and c-myc are rearranged. We cloned the rearranged c-myc and found that it was translocated to the immunoglobulin Cα locus. The breakpoint is at the end of exon 1 in c-myc and approximately 0.5 kb upstream from exon 1 of Cα. The cloned translocated c-myc linked to a strong transcriptional promoter can efficiently transform rat embryo fibroblasts when co-transfected with the activated Ha-ras. The transformed cells are tumorigenic in syngeneic rats.
Original language | English |
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Pages (from-to) | 297-300 |
Number of pages | 4 |
Journal | Gene |
Volume | 48 |
Issue number | 2-3 |
DOIs | |
State | Published - 1986 |
Externally published | Yes |
Keywords
- Recombinant DNA
- cell transformation
- genome rearrangement
- oncogenes