Structural wrinkles and the genomic regulatory sites of eukaryotes

Ruth Nussinov*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Calculations of DNA angular parameters in 50 eukaryotic sequences reveal regions of large conformational deviations from ideal DNA around regulatory sites. Frequently, discrete peaks of structural variation are present upstream of genes. Known regulatory regions often include variants of consensus sequences. Thus, imprecise sequences and structures are recognized within large genomic stretches. The existence of structurally "wrinkled" regions in the vicinity of regulatory sequences is likely to facilitate greatly their recognition by proteins and enzymes.

Original languageEnglish
Pages (from-to)150-159
Number of pages10
JournalJournal of Molecular Evolution
Issue number2
StatePublished - Oct 1985
Externally publishedYes


  • Chromatin structure
  • Regulation
  • Structural computations


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