Structural correlates of seizure behavior in the Mongolian gerbil

Linda A. Paul; Itzhak Fried; Kathy Watanabe; Alan B. Forsythe; Arnold B. Scheibel

doi:10.1126/science.7256289

Structural correlates of seizure behavior in the Mongolian gerbil

Linda A. Paul^*, Itzhak Fried, Kathy Watanabe, Alan B. Forsythe, Arnold B. Scheibel

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

Abstract

Hippocampi of seizure-sensitive and seizure-resistant Mongolian gerbils were examined in search of structural correlates of seizure behavior. In animal well-established seizure histories, differences were found in both presynaptic and postsynaptic structures. Seizing animals had less dense dendritic spines, a greater proportion of mossy tuft area devoted to presynaptic vesicles, and a smaller proportion devoted to spines. The possible relationship of these findings to epilepsy is discussed.

Original language	English
Pages (from-to)	924-926
Number of pages	3
Journal	Science
Volume	213
Issue number	4510
DOIs	https://doi.org/10.1126/science.7256289
State	Published - 1981
Externally published	Yes

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10.1126/science.7256289

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title = "Structural correlates of seizure behavior in the Mongolian gerbil",

abstract = "Hippocampi of seizure-sensitive and seizure-resistant Mongolian gerbils were examined in search of structural correlates of seizure behavior. In animal well-established seizure histories, differences were found in both presynaptic and postsynaptic structures. Seizing animals had less dense dendritic spines, a greater proportion of mossy tuft area devoted to presynaptic vesicles, and a smaller proportion devoted to spines. The possible relationship of these findings to epilepsy is discussed.",

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AU - Watanabe, Kathy

AU - Forsythe, Alan B.

AU - Scheibel, Arnold B.

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AB - Hippocampi of seizure-sensitive and seizure-resistant Mongolian gerbils were examined in search of structural correlates of seizure behavior. In animal well-established seizure histories, differences were found in both presynaptic and postsynaptic structures. Seizing animals had less dense dendritic spines, a greater proportion of mossy tuft area devoted to presynaptic vesicles, and a smaller proportion devoted to spines. The possible relationship of these findings to epilepsy is discussed.

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Structural correlates of seizure behavior in the Mongolian gerbil

Abstract

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