Structural correlates of seizure behavior in the Mongolian gerbil

Linda A. Paul*, Itzhak Fried, Kathy Watanabe, Alan B. Forsythe, Arnold B. Scheibel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Hippocampi of seizure-sensitive and seizure-resistant Mongolian gerbils were examined in search of structural correlates of seizure behavior. In animal well-established seizure histories, differences were found in both presynaptic and postsynaptic structures. Seizing animals had less dense dendritic spines, a greater proportion of mossy tuft area devoted to presynaptic vesicles, and a smaller proportion devoted to spines. The possible relationship of these findings to epilepsy is discussed.

Original languageEnglish
Pages (from-to)924-926
Number of pages3
Issue number4510
StatePublished - 1981
Externally publishedYes


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