Structural and functional studies on insulin receptors from alligator brain and liver

J. Shemer*, M. Raizada, D. LeRoith

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

1. 1. Insulin receptors are present in membranes prepared from Alligator mississippiensis brain and liver. 2. 2. The apparent molecular weight (MW) of the α subunits are 132 kDa and 118 kDa in liver and brain respectively. 3. 3. Apparent MW of the β subunit is 92 kDa in both brain and liver receptors. 4. 4. Despite the structural differences between brain and liver α subunits, brain insulin receptors demonstrate the normal coupling between α and β subunits, i.e. following binding of insulin to the α subunit the β subunit undergoes autophophorylation and stimulates tyrosine specific phosphorylation of exogenously added substrates. 5. 5. These findings suggest that functional insulin receptors are evolutionarily well conserved.

Original languageEnglish
Pages (from-to)55-61
Number of pages7
JournalComparative Biochemistry and Physiology - B Biochemistry and Molecular Biology
Volume86
Issue number1
DOIs
StatePublished - 1987
Externally publishedYes

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