TY - JOUR
T1 - Structural and functional properties of the membranotropic HIV-1 glycoprotein gp41 loop region are modulated by its intrinsic hydrophobic core
AU - Qiu, Jiayin
AU - Ashkenazi, Avraham
AU - Liu, Shuwen
AU - Shai, Yechiel
PY - 2013/10/4
Y1 - 2013/10/4
N2 - Background:HIV-1 infectivity is decreased by specific mutations that alter the hydrophobicity level in the HIV-1 gp41 loop core. Results:Antibody recognition, disulfide-bond formation, and lipid mixing of loop domain peptides are strongly affected by these mutations. Conclusion:The hydrophobic core maintains proper function and structure of the loop region. Significance:A better understanding of the membrane fusion mechanism of HIV and similar viruses is provided.
AB - Background:HIV-1 infectivity is decreased by specific mutations that alter the hydrophobicity level in the HIV-1 gp41 loop core. Results:Antibody recognition, disulfide-bond formation, and lipid mixing of loop domain peptides are strongly affected by these mutations. Conclusion:The hydrophobic core maintains proper function and structure of the loop region. Significance:A better understanding of the membrane fusion mechanism of HIV and similar viruses is provided.
UR - https://www.scopus.com/pages/publications/84885098420
U2 - 10.1074/jbc.M113.496646
DO - 10.1074/jbc.M113.496646
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AN - SCOPUS:84885098420
SN - 0021-9258
VL - 288
SP - 29143
EP - 29150
JO - Journal of Biological Chemistry
JF - Journal of Biological Chemistry
IS - 40
ER -
