Abstract
In this paper we discuss the constraints and combinatorial problems of folding long RNA and single stranded DNA molecules into base paired structures. A computer code FOLD-A was designed to perform base pairing foldings of very long sequence chains and search for low energy configurations. The logic of the FOLD-A algorithm is described in some detail. The applications of FOLD-A to the A-protein gene of MS2 and the whole genome of the φX 174 phage with over 5300 bases are discussed in the accompanying paper.
Original language | English |
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Pages (from-to) | 245-259 |
Number of pages | 15 |
Journal | Journal of Theoretical Biology |
Volume | 106 |
Issue number | 3 |
DOIs | |
State | Published - 7 Feb 1984 |
Externally published | Yes |