@article{903c435afc4542d59b6a885366561dc5,
title = "Structural and combinatorial constraints on base pairing in large nucleotide sequences",
abstract = "In this paper we discuss the constraints and combinatorial problems of folding long RNA and single stranded DNA molecules into base paired structures. A computer code FOLD-A was designed to perform base pairing foldings of very long sequence chains and search for low energy configurations. The logic of the FOLD-A algorithm is described in some detail. The applications of FOLD-A to the A-protein gene of MS2 and the whole genome of the φX 174 phage with over 5300 bases are discussed in the accompanying paper.",
author = "Ruth Nussinov and George Pieczenik",
note = "Funding Information: To Dr Barbara Brodsky of the Rutger{\textquoteright}s Medical School, we express our thanks for her continuing interest encouragement during the course of our work. We would also like to thank C.C.I.S. Hill Center at Rutger{\textquoteright}s University for computer facilities. This work was supported in part by grant NIH-GM.",
year = "1984",
month = feb,
day = "7",
doi = "10.1016/0022-5193(84)90029-8",
language = "אנגלית",
volume = "106",
pages = "245--259",
journal = "Journal of Theoretical Biology",
issn = "0022-5193",
publisher = "Academic Press",
number = "3",
}