Strong association between mRNA folding strength and protein abundance in S. cerevisiae

Hadas Zur, Tamir Tuller

Research output: Contribution to journalArticlepeer-review

Abstract

One of the open questions in regulatory genomics is how the efficiency of gene translation is encoded in the coding sequence. Here we analyse recently generated measurements of folding energy in Saccharomyces cerevisiae, showing that genes with high protein abundance tend to have strong mRNA folding (mF; R=0.68). mF strength also strongly correlates with ribosomal density and mRNA levels, suggesting that this relation at least partially pertains to the efficiency of translation elongation, presumably by preventing aggregation of mRNA molecules.

Original languageEnglish
Pages (from-to)272-277
Number of pages6
JournalEMBO Reports
Volume13
Issue number3
DOIs
StatePublished - Mar 2012

Keywords

  • gene translation
  • mRNA aggregation
  • mRNA folding
  • protein abundance
  • translation elongation

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