Striatin is a novel modulator of cell adhesion

Lital Lahav-Ariel, Michal Caspi, Prathamesh T. Nadar-Ponniah, Natalie Zelikson, Ilse Hofmann, Kirsten K. Hanson, Werner W. Franke, Ella H. Sklan, Karen B. Avraham, Rina Rosin-Arbesfeld*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The adherens junctions (AJs) and tight junctions (TJs) provide critical adhesive contacts between neighboring epithelial cells and are crucial for epithelial adhesion, integrity, and barrier functions in a wide variety of tissues and organisms. The striatin protein family, which are part of the striatin interaction phosphatases and kinases complex, are multidomain scaffolding proteins that play important biologic roles. We have previously shown that striatin colocalizes with the tumor suppressor protein adenomatous polyposis coli in the TJs of epithelial cells. Here we show that striatin affects junction integrity and cell migration, probably through a mechanism that involves the adhesion molecule E-cadherin. Cells engaged in cell-cell adhesion expressed a high MW-modified form of striatin that forms stable associations with detergent-insoluble, membrane-bound cellular fractions. In addition, striatin has recently been suggested to be a target of the poly (ADP-ribose) polymerases Tankyrase 1, and we have found that striatin interacts with Tankyrase 1 and is subsequently poly-ADP-ribosylated. Taken together, our results suggest that striatin is a novel cell-cell junctional protein that functions to maintain correct cell adhesion and may have a role in establishing the relationship between AJs and TJs that is fundamental for epithelial cell-cell adhesion.

Original languageEnglish
Pages (from-to)4729-4740
Number of pages12
JournalFASEB Journal
Issue number4
StatePublished - 2019


FundersFunder number
Gateway for Cancer Research Foundation
National Institutes of Health
National Institute on Deafness and Other Communication DisordersR01DC011835
German-Israeli Foundation for Scientific Research and Development1098
United States-Israel Binational Science Foundation2017173
Israel Science Foundation829/14
Rising Tide Foundation for Clinical Cancer Research


    • Cell-cell junctions
    • Epithelial cells
    • Tight junctions
    • Wnt signaling


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