Striatal adenylate cyclase activity following reserpine and chronic chlorpromazine administration in rats

John Rotrosen, Eitan Friedman, Samuel Gershon

Research output: Contribution to journalArticlepeer-review

Abstract

Adenylate cyclase activity was assayed in rat striatal homogenates. Dopamine and, to a lesser extent, 1-norepinephrine added in vitro produced a dose-dependent enhancement of adenylate cyclase activity. Fluphenazine did not alter basal enzyme activity, but prevented both dopamine- and 1-norepinephrine-elicited increases. No significant changes in basal- or dopamine-stimulated adenylate cyclase activity were found in homogenates from rats pretreated with chlorpromazine for 21 days or reserpine for 2 days. It is concluded that the behavioral and neurophysiologic postsynaptic supersensitivities that follow similar pretreatments are not mediated by alterations in the sensitivity of striatal adenylate cyclase to dopamine.

Original languageEnglish
Pages (from-to)563-568
Number of pages6
JournalLife Sciences
Volume17
Issue number4
DOIs
StatePublished - 15 Aug 1975
Externally publishedYes

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