Striatal adenylate cyclase activity following reserpine and chronic chlorpromazine administration in rats

John Rotrosen; Eitan Friedman; Samuel Gershon

doi:10.1016/0024-3205(75)90091-0

Striatal adenylate cyclase activity following reserpine and chronic chlorpromazine administration in rats

John Rotrosen, Eitan Friedman, Samuel Gershon

Research output: Contribution to journal › Article › peer-review

Abstract

Adenylate cyclase activity was assayed in rat striatal homogenates. Dopamine and, to a lesser extent, 1-norepinephrine added in vitro produced a dose-dependent enhancement of adenylate cyclase activity. Fluphenazine did not alter basal enzyme activity, but prevented both dopamine- and 1-norepinephrine-elicited increases. No significant changes in basal- or dopamine-stimulated adenylate cyclase activity were found in homogenates from rats pretreated with chlorpromazine for 21 days or reserpine for 2 days. It is concluded that the behavioral and neurophysiologic postsynaptic supersensitivities that follow similar pretreatments are not mediated by alterations in the sensitivity of striatal adenylate cyclase to dopamine.

Original language	English
Pages (from-to)	563-568
Number of pages	6
Journal	Life Sciences
Volume	17
Issue number	4
DOIs	https://doi.org/10.1016/0024-3205(75)90091-0
State	Published - 15 Aug 1975
Externally published	Yes

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title = "Striatal adenylate cyclase activity following reserpine and chronic chlorpromazine administration in rats",

abstract = "Adenylate cyclase activity was assayed in rat striatal homogenates. Dopamine and, to a lesser extent, 1-norepinephrine added in vitro produced a dose-dependent enhancement of adenylate cyclase activity. Fluphenazine did not alter basal enzyme activity, but prevented both dopamine- and 1-norepinephrine-elicited increases. No significant changes in basal- or dopamine-stimulated adenylate cyclase activity were found in homogenates from rats pretreated with chlorpromazine for 21 days or reserpine for 2 days. It is concluded that the behavioral and neurophysiologic postsynaptic supersensitivities that follow similar pretreatments are not mediated by alterations in the sensitivity of striatal adenylate cyclase to dopamine.",

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N2 - Adenylate cyclase activity was assayed in rat striatal homogenates. Dopamine and, to a lesser extent, 1-norepinephrine added in vitro produced a dose-dependent enhancement of adenylate cyclase activity. Fluphenazine did not alter basal enzyme activity, but prevented both dopamine- and 1-norepinephrine-elicited increases. No significant changes in basal- or dopamine-stimulated adenylate cyclase activity were found in homogenates from rats pretreated with chlorpromazine for 21 days or reserpine for 2 days. It is concluded that the behavioral and neurophysiologic postsynaptic supersensitivities that follow similar pretreatments are not mediated by alterations in the sensitivity of striatal adenylate cyclase to dopamine.

AB - Adenylate cyclase activity was assayed in rat striatal homogenates. Dopamine and, to a lesser extent, 1-norepinephrine added in vitro produced a dose-dependent enhancement of adenylate cyclase activity. Fluphenazine did not alter basal enzyme activity, but prevented both dopamine- and 1-norepinephrine-elicited increases. No significant changes in basal- or dopamine-stimulated adenylate cyclase activity were found in homogenates from rats pretreated with chlorpromazine for 21 days or reserpine for 2 days. It is concluded that the behavioral and neurophysiologic postsynaptic supersensitivities that follow similar pretreatments are not mediated by alterations in the sensitivity of striatal adenylate cyclase to dopamine.

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Striatal adenylate cyclase activity following reserpine and chronic chlorpromazine administration in rats

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