Stress reaction to intense sound exposure under different arousal levels in guinea pigs

Chava Muchnik*, Talma Rosenthal, Edna Peleg, Minka Hildesheimer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The general impact of high intensity sound exposure on 25 guinea pigs was investigated at three different levels of arousal: 10 during general anaesthesia, 10 during partial arousal, and 5 during complete arousal. Parameters recorded before and during noise exposure were mean arterial blood pressure, pulse rate, and plasma norepinephrine levels. The anaesthetized group showed no increase in the three parameters during sound exposure. Under partial arousal, pulse rate and norepinephrine level increased significantly: pulse rate from 224.5 beats/min before exposure to 278.6 beats/min during exposure, and norepinephrine level from 558 pg/ml before sound exposure to 1276 pg/ml during exposure. At the time of the complete arousal state norepinephrine and pulse rates increased significantly during noise exposure, while blood pressure showed no additional increase as a result of sound exposure.

Original languageEnglish
Pages (from-to)646-650
Number of pages5
JournalActa Oto-Laryngologica
Issue number5
StatePublished - 1998
Externally publishedYes


  • Guinea pigs
  • Norepinephrine
  • Sound exposure
  • Stress reaction


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