TY - JOUR
T1 - Stress-induced mutagenesis and complex adaptation
AU - Ram, Yoav
AU - Hadany, Lilach
PY - 2014/8/20
Y1 - 2014/8/20
N2 - Because mutations are mostly deleterious, mutation rates should be reduced by natural selection. However, mutations also provide the raw material for adaptation. Therefore, evolutionary theory suggests that the mutation rate must balance between adaptability-the ability to adapt-and adaptedness-the ability to remain adapted. We model an asexual population crossing a fitness valley and analyse the rate of complex adaptation with and without stress-induced mutagenesis (SIM)-the increase of mutation rates in response to stress or maladaptation. We show that SIM increases the rate of complex adaptation without reducingthepopulationmeanfitness, thus breaking the evolutionary trade-off between adaptability and adaptedness. Our theoretical results support the hypothesis that SIM promotes adaptation and provide quantitative predictions of the rate of complex adaptation with different mutational strategies.
AB - Because mutations are mostly deleterious, mutation rates should be reduced by natural selection. However, mutations also provide the raw material for adaptation. Therefore, evolutionary theory suggests that the mutation rate must balance between adaptability-the ability to adapt-and adaptedness-the ability to remain adapted. We model an asexual population crossing a fitness valley and analyse the rate of complex adaptation with and without stress-induced mutagenesis (SIM)-the increase of mutation rates in response to stress or maladaptation. We show that SIM increases the rate of complex adaptation without reducingthepopulationmeanfitness, thus breaking the evolutionary trade-off between adaptability and adaptedness. Our theoretical results support the hypothesis that SIM promotes adaptation and provide quantitative predictions of the rate of complex adaptation with different mutational strategies.
KW - Adaptive peak shifts
KW - Evolvability
KW - Mathematical model
KW - Mutation rate
KW - Stress-induced variation
KW - Trade-off
UR - http://www.scopus.com/inward/record.url?scp=85006284588&partnerID=8YFLogxK
U2 - 10.1098/rspb.2014.1025
DO - 10.1098/rspb.2014.1025
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AN - SCOPUS:85006284588
SN - 0962-8452
VL - 281
JO - Proceedings of the Royal Society B: Biological Sciences
JF - Proceedings of the Royal Society B: Biological Sciences
IS - 1792
M1 - 20141025
ER -