Stress in the emergency room: A simple leukocyte to glass adhesion test provides a diagnostic tool to differentiate between stress and infection/inflammation related leukocytosis

Gill Fier, Yifaat Sasson, Ori Rogovsky, Eliezer Liberman, Eyal Leibovitz, Pinchas Halperin, Jack Sarov, Nadir Arber, Farjad Sarafian, David Seltzer, Shlomo Berliner

Research output: Contribution to journalArticlepeer-review

Abstract

In order to discriminate between stress-induced leukocytosis and an infection/inflammation-related one, we have used a modified leukocyte adhesiveness/aggregation test (LAAT) to examine the adhesive properties of white blood cells towards glass surfaces. A highly significant p < 0.00001) difference was noted between the percent of aggregated cells found in a group of patients with various conditions of infection/inflammation (22.9 ± 6.4%) and those with stress (7.5 ± 1.4%). The corresponding difference between the total white blood cell count in the peripheral blood of these two groups (16,547 ± 3289 and 14,114 ± 4898 cells per mm3, respectively) was not significant. The difference in total leukocytes adhered to the glass in the two groups (445 ± 136 vs 228 ± 72 cells per high power field) that were determined along the slide was also highly significant (p < 0.00001). Thus, a simple glass slide technique might be of clinical utility for an effective, rapid and inexpensive means of discrimination between stress and infection/inflammation related leukocytosis.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalStress Medicine
Volume15
Issue number3
DOIs
StatePublished - 1999

Keywords

  • Inflammation
  • Leukocyte adhesiveness
  • Stress

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