TY - JOUR
T1 - Stress and Autoimmunity
T2 - The Neuropeptides Corticotropin-Releasing Factor and Urocortin Suppress Encephalomyelitis via Effects on Both the Hypothalamic-Pituitary-Adrenal Axis and the Immune System
AU - Poliak, Sebastian
AU - Mor, Felix
AU - Conlon, Paul
AU - Wong, Tim
AU - Ling, Nick
AU - Rivier, Jean
AU - Vale, Wylie
AU - Steinman, Lawrence
PY - 1997/6/15
Y1 - 1997/6/15
N2 - Corticotropin-releasing factor (CRF) exerts a major role in the stress response. Both CRF and urocortin, a newly discovered neuropeptide homologous to CRF, suppressed experimental autoimmune encephalomyelitis (EAE). Suppression of paralysis with CRF involved stimulation of the hypothalamic-pituitary-adrenal axis and inhibitory effects on an encephalitogenic T cell line. While CRF increased glucocorticoid production, which is known to block EAE, it also suppressed EAE in adrenalectomized rats, where glucocorticoid stimulation via CRF plays no role. Moreover, the encephalitogenicity of a T cell line exposed to CRF in vitro was reduced. Stress may influence autoimmune disease through the hypothalamic-pituitary-adrenal axis and directly via the immune system.
AB - Corticotropin-releasing factor (CRF) exerts a major role in the stress response. Both CRF and urocortin, a newly discovered neuropeptide homologous to CRF, suppressed experimental autoimmune encephalomyelitis (EAE). Suppression of paralysis with CRF involved stimulation of the hypothalamic-pituitary-adrenal axis and inhibitory effects on an encephalitogenic T cell line. While CRF increased glucocorticoid production, which is known to block EAE, it also suppressed EAE in adrenalectomized rats, where glucocorticoid stimulation via CRF plays no role. Moreover, the encephalitogenicity of a T cell line exposed to CRF in vitro was reduced. Stress may influence autoimmune disease through the hypothalamic-pituitary-adrenal axis and directly via the immune system.
UR - http://www.scopus.com/inward/record.url?scp=0031570394&partnerID=8YFLogxK
U2 - 10.4049/jimmunol.158.12.5751
DO - 10.4049/jimmunol.158.12.5751
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C2 - 9190925
AN - SCOPUS:0031570394
SN - 0022-1767
VL - 158
SP - 5751
EP - 5756
JO - Journal of Immunology
JF - Journal of Immunology
IS - 12
ER -