Stimulatory effect of prostaglandin E2 on LH release in the rat: Evidence for hypothalamic site of action

P. Chobsieng; Z. Naor; Y. Koch; U. Zor; H. R. Lindner

doi:10.1159/000122336

Stimulatory effect of prostaglandin E₂ on LH release in the rat: Evidence for hypothalamic site of action

P. Chobsieng, Z. Naor, Y. Koch, U. Zor, H. R. Lindner^*

^*Corresponding author for this work

Weizmann Institute of Science

Research output: Contribution to journal › Article › peer-review

48 Scopus citations

Abstract

The intravenous administration of prostaglandin E₂ (PGE₂; 100 μg/rat) to immature male and female rats increased the serum level of luteinizing hormone (LH). This effect was prevented by the prior administration of an antiserum to the hypothalamic gonadotropin-releasing hormone. LH release from rat pituitaries in vitro was not stimulated by PGE₂ (10 μg/ml). It is inferred that the stimulatory effect of PGE₂, on LH release is not a direct one on the pituitary gland, but is exerted at the level of the hypothalamus.

Original language	English
Pages (from-to)	12-17
Number of pages	6
Journal	Neuroendocrinology
Volume	17
Issue number	1
DOIs	https://doi.org/10.1159/000122336
State	Published - 1975
Externally published	Yes

Keywords

Antiserum to LH-RH
Hypothalamus
LH release
LH-RH
Pituitary gland
Prostaglandin E

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10.1159/000122336

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abstract = "The intravenous administration of prostaglandin E2 (PGE2; 100 μg/rat) to immature male and female rats increased the serum level of luteinizing hormone (LH). This effect was prevented by the prior administration of an antiserum to the hypothalamic gonadotropin-releasing hormone. LH release from rat pituitaries in vitro was not stimulated by PGE2 (10 μg/ml). It is inferred that the stimulatory effect of PGE2, on LH release is not a direct one on the pituitary gland, but is exerted at the level of the hypothalamus.",

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Stimulatory effect of prostaglandin E₂ on LH release in the rat: Evidence for hypothalamic site of action

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Keywords

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