TY - JOUR
T1 - Stimulation of prostaglandin e production by bacterial endotoxins in cultured human synovial fibroblasts
AU - Yaron, Michael
AU - Yaron, Ilana
AU - Smetana, Ophyra
AU - Eylan, Emanuel
AU - Zor, Uriel
PY - 1980/8
Y1 - 1980/8
N2 - E coli, shigella, salmonella, and cholera endotoxins stimulated prostaglandin E (PGE) production by cultured human synovial and foreskin fibroblasts. The minimal effective dose of Shigella endotoxin was 2 μg/ml and a maximal response was observed at 10 μg/ml. PGE stimulation was first detected 7 hours after addition of cholera endotoxin. Stimulation by shigelia endotoxin of both PGE and hyaluronic acid production was inhibited by indomethacin and aspirin. The present results suggest that PGE is a mediator of joint inflammation induced by endotoxins.
AB - E coli, shigella, salmonella, and cholera endotoxins stimulated prostaglandin E (PGE) production by cultured human synovial and foreskin fibroblasts. The minimal effective dose of Shigella endotoxin was 2 μg/ml and a maximal response was observed at 10 μg/ml. PGE stimulation was first detected 7 hours after addition of cholera endotoxin. Stimulation by shigelia endotoxin of both PGE and hyaluronic acid production was inhibited by indomethacin and aspirin. The present results suggest that PGE is a mediator of joint inflammation induced by endotoxins.
UR - http://www.scopus.com/inward/record.url?scp=0018926666&partnerID=8YFLogxK
U2 - 10.1002/art.1780230807
DO - 10.1002/art.1780230807
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C2 - 6157394
AN - SCOPUS:0018926666
SN - 0004-3591
VL - 23
SP - 921
EP - 925
JO - Arthritis and Rheumatology
JF - Arthritis and Rheumatology
IS - 8
ER -
