Stimulation of myeloid colony development elaborated by colony forming cells-Fibroblasts from rat developing ossicles

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Abstract

Subcutaneous implantation of demineralized bone matrix in rats results in endochondral bone formation and bone-marrow development. The cascade of events leading to this process occurs following the accumulation of mesenchymal cells with colony forming cell fibroblasts (CFC-F) potential in the implanted area, a process which commences already 72 h post implantation. It is demonstrated herein that CFC-F from various stages of ossicle development (days, 3, 7, 10, 14 or 18) stimulate hemopoiesis to the same extent as judged by the number of granuloid-macrophage-progenitors (CFU-GM), developed as hemopoietic colonies, and by the ratio of granuloid to macrophagic colonies. High concentrations of CFC-F, however, tend to diminish the stimulatory capacity. Prostaglandin E, CFU-GM, CFC-F, ossicle, growth factors, microenvironment, hemopoiesis, development.

Original languageEnglish
Pages (from-to)63-68
Number of pages6
JournalLeukemia Research
Volume14
Issue number1
DOIs
StatePublished - 1990

Keywords

  • 9 microenvironment
  • CFC-F
  • CFU-GM
  • growth factors
  • hemopoiesis
  • ossicle

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