Stimulation of murine amyloidosis by a dializable product from pretreated donors

Amyloid was obtained in recipient mice by implantation into their peritoneal cavity of a dialysis bag containing spleen cells obtained from donor mice which were treated with casein for 6 days and while no amyloid was found in their implanted spleens. The transplantations were performed with 2 cell systems, one containing whole spleen suspension and the other washed cells. Amyloid was obtained in the recipient mice within 6 days after the implantation and in a more massive quantity than in mice treated by casein for a similar period. Among the recipients of normal whole spleen suspension of untreated mice, none of 17 had amyloid 6 days later. The contents of all the implanted bags were examined for amyloid after the recipient mice were killed and in none was amyloid found.