Stimulated single-fiber electromyography in Lambert-Eaton myasthenic syndrome before and after 3,4-diaminopyridine

Menachem Sadeh, Yaron River, Zohar Argov

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with LEMS unrelated to cancer was studied by stimulated single-fiber electromyography (SFEMG) before and 3 months after the onset of therapy with 3,4-diaminopyridine. All end-plates showed a progressive reduction in blockings and jitter with the increase in stimulation rate. Treatment significantly corrected this feature, but the overall pattern of frequency-improved jitter remained. Such widespread finding is rare but diagnostic for Lambert-Eaton myasthenic syndrome. Stimulated SFEMG can be used to monitor therapy in such patients.

Original languageEnglish
Pages (from-to)735-739
Number of pages5
JournalMuscle and Nerve
Volume20
Issue number6
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • 3,4- diaminopyridine
  • Lambert-Eaton myasthenic syndrome
  • single-fiber electromyography

Fingerprint

Dive into the research topics of 'Stimulated single-fiber electromyography in Lambert-Eaton myasthenic syndrome before and after 3,4-diaminopyridine'. Together they form a unique fingerprint.

Cite this