Steroid-responsive, progressive, focal measles virus brain infection

Israel Steiner; Vered Livneh; Chen Hoffmann; Dvora Nass; Orna Mor; Joab Chapman

doi:10.1002/ana.24183

Steroid-responsive, progressive, focal measles virus brain infection

Israel Steiner^*, Vered Livneh, Chen Hoffmann, Dvora Nass, Orna Mor, Joab Chapman

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Scopus citations

Abstract

Chronic measles virus infection of the brain causes subacute sclerosing panencephalitis (SSPE), a progressive, relentless fatal disorder. We report a 52-year-old male who developed focal, chronic persistent measles virus infection of the brain following interferon and ribavirin therapy for hepatitis C, and who responded to steroid therapy. This case, diametrically different from SSPE, has 2 unique features, its focal nature and its permissive response to steroids, that may add to the understanding of the pathogenesis of SSPE and the mechanism enabling viruses to evade the immune response and establish persistent brain infection. Ann Neurol 2014;75:967-970

Original language	English
Pages (from-to)	967-970
Number of pages	4
Journal	Annals of Neurology
Volume	75
Issue number	6
DOIs	https://doi.org/10.1002/ana.24183
State	Published - Jun 2014

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10.1002/ana.24183

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title = "Steroid-responsive, progressive, focal measles virus brain infection",

abstract = "Chronic measles virus infection of the brain causes subacute sclerosing panencephalitis (SSPE), a progressive, relentless fatal disorder. We report a 52-year-old male who developed focal, chronic persistent measles virus infection of the brain following interferon and ribavirin therapy for hepatitis C, and who responded to steroid therapy. This case, diametrically different from SSPE, has 2 unique features, its focal nature and its permissive response to steroids, that may add to the understanding of the pathogenesis of SSPE and the mechanism enabling viruses to evade the immune response and establish persistent brain infection. Ann Neurol 2014;75:967-970",

author = "Israel Steiner and Vered Livneh and Chen Hoffmann and Dvora Nass and Orna Mor and Joab Chapman",

year = "2014",

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T1 - Steroid-responsive, progressive, focal measles virus brain infection

AU - Steiner, Israel

AU - Livneh, Vered

AU - Hoffmann, Chen

AU - Nass, Dvora

AU - Mor, Orna

AU - Chapman, Joab

PY - 2014/6

Y1 - 2014/6

N2 - Chronic measles virus infection of the brain causes subacute sclerosing panencephalitis (SSPE), a progressive, relentless fatal disorder. We report a 52-year-old male who developed focal, chronic persistent measles virus infection of the brain following interferon and ribavirin therapy for hepatitis C, and who responded to steroid therapy. This case, diametrically different from SSPE, has 2 unique features, its focal nature and its permissive response to steroids, that may add to the understanding of the pathogenesis of SSPE and the mechanism enabling viruses to evade the immune response and establish persistent brain infection. Ann Neurol 2014;75:967-970

AB - Chronic measles virus infection of the brain causes subacute sclerosing panencephalitis (SSPE), a progressive, relentless fatal disorder. We report a 52-year-old male who developed focal, chronic persistent measles virus infection of the brain following interferon and ribavirin therapy for hepatitis C, and who responded to steroid therapy. This case, diametrically different from SSPE, has 2 unique features, its focal nature and its permissive response to steroids, that may add to the understanding of the pathogenesis of SSPE and the mechanism enabling viruses to evade the immune response and establish persistent brain infection. Ann Neurol 2014;75:967-970

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JO - Annals of Neurology

JF - Annals of Neurology

IS - 6

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Steroid-responsive, progressive, focal measles virus brain infection

Abstract

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