Steroid-induced reversible dementia

Z. Wiener*, D. Aizenberg, Z. Zemishlany

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A reversible dementia-like syndrome is a rare manifestation of corticosteroid medication and few cases have been reported. Steroid dementia is characterized by deficits in memory retention, attention, concentration and occupational performance. Symptoms are reversed following discontinuation or reduction of dosage. It is likely that steroid dementia is an extreme manifestation of the cognitive impairment frequently associated with excessive levels of endogenous and exogenous corticosteroids. We present a 57-year-old man who developed the syndrome of reversible dementia while being treated with prednisone for pemphigus. The impairment in memory, orientation, judgement and everyday functioning necessitated admission to a closed psychiatric ward. Following reduction in prednisone dosage, all psychiatric manifestations disappeared within 30 days.

Original languageEnglish
Pages (from-to)28-29+62
Issue number1
StatePublished - 1995
Externally publishedYes


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