Steroid 11β-hydroxylase activity in the microsomal fraction of human adrenals

A. Klein, R. Siebenmann, H. Ch Curtius, M. Zachmann

Research output: Contribution to journalArticlepeer-review

Abstract

The conversion of 11-deoxycortisol and 11-deoxycorticosterone (DOC) to their 11β-hydroxylated metabolites was measured in the 20,000 and 105,000 g fractions of human adrenals. The adrenals were obtained from kidney transplantation donors. The results indicate the presence of relatively high 11β-hydroxylase activity in the microsomal fraction which cannot be attributed to enzyme contamination. In addition there would seem to be further metabolism of cortisol probably by an 17α-hydroxysteroid side chain cleavage enzyme.

Original languageEnglish
Pages (from-to)283-287
Number of pages5
JournalJournal of Steroid Biochemistry
Volume7
Issue number4
DOIs
StatePublished - Apr 1976
Externally publishedYes

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