Stepping up to meet the challenge of freezing of gait in Parkinson’s disease

Simon Lewis*, Stewart Factor, Nir Giladi, Alice Nieuwboer, John Nutt, Mark Hallett

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

There has been a growing appreciation for freezing of gait as a disabling symptom that causes a significant burden in Parkinson’s disease. Previous research has highlighted some of the key components that underlie the phenomenon, but these reductionist approaches have yet to lead to a paradigm shift resulting in the development of novel treatment strategies. Addressing this issue will require greater integration of multi-modal data with complex computational modeling, but there are a number of critical aspects that need to be considered before embarking on such an approach. This paper highlights where the field needs to address current gaps and shortcomings including the standardization of definitions and measurement, phenomenology and pathophysiology, as well as considering what available data exist and how future studies should be constructed to achieve the greatest potential to better understand and treat this devastating symptom.

Original languageEnglish
Article number23
JournalTranslational Neurodegeneration
Volume11
Issue number1
DOIs
StatePublished - Dec 2022

Funding

FundersFunder number
Aufzien Academic Center in Tel-Aviv University
European Commission, Research Foundation Flanders
Parkinson’s Foundation
Sartain Lanier Family Foundation
Sieratzki Family Foundation
Sun Pharmaceuticals Advanced Research Company
Sunovion Therapeutics
National Institutes of Health
National Institute of Neurological Disorders and StrokeZIANS003031
Michael J. Fox Foundation for Parkinson's Research
National Parkinson Foundation
Medtronic
Biogen
CHDI Foundation
International Parkinson and Movement Disorder Society
Boston Scientific Corporation
European Commission
Australian Research Council
National Health and Medical Research Council1195830
Israel Science Foundation
KU Leuven
Koning Boudewijnstichting

    Keywords

    • Computational modeling
    • Freezing of gait
    • Novel paradigms
    • Pathophysiology
    • Phenomenology
    • Standardized definitions and assessments
    • Treatment

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