Stem cells commitment on graphene-based Scaffolds

Maurizio Buggio, Marco Tatullo, Stefano Sivolella, Chiara Gardin, Letizia Ferroni, Eitan Mijiritsky, Adriano Piattelli, Barbara Zavan*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

In the last years, a rapid development in production, and functionalization of graphene give rise to several products that have shown great potentials in many fields, such as nanoelectronics, energy technology, sensors, and catalysis. In this context we should not forget the biomedical application of graphene that became a new area with outstanding potential. The first study on graphene for biomedical applications has been performed by Dai in 2008 that reported the use of graphene oxide as an efficient nanocarrier for drug delivery. This pioneristic study opened the doors for the use of graphene in widespread biomedical applications such as drug/gene delivery, biological sensing and imaging, antibacterial materials, but also as biocompatible scaffold for cell culture and tissue engineering. The application of graphene-based scaffolds for tissue engineering applications is confirmed by the many exciting and intriguing literature reports over the last few years, that clearly confirm that graphene and its related substrates are excellent platforms for adhesion, proliferation, and differentiation of various cells such as human Mesenchymal stem cells, human neuronal stem cells, and induced pluripotent stem cells. Since most of the papers on this fields are related to in vitro studies, several future in vivo investigations need to be conducted in order to lead to its utilization as implantable tissue engineering material.

Original languageEnglish
Title of host publicationCarbon Nanostructures
PublisherSpringer International Publishing
Pages103-133
Number of pages31
Edition9783319456379
DOIs
StatePublished - 2016

Publication series

NameCarbon Nanostructures
Number9783319456379
Volume0
ISSN (Print)2191-3005
ISSN (Electronic)2191-3013

Keywords

  • Embryonic stem cell
  • Graphene oxide
  • Mesenchymal stem cell
  • Stem cell
  • Tissue engineering

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