@article{1a88aa97dca944c0a8a02255353eb205,
title = "Stem cell-based therapy for prevention of delayed fracture union: A randomized and prospective preliminary study",
abstract = "Distal tibial fractures tend towards delayed- or nonunion. The purpose of this study was to evaluate the safety and efficacy of early minimally invasive intervention (MII) in the treatment of these fractures. A total 24 consecutive patients who underwent operative treatment for distal tibial fractures were randomized into a control and an intervention group. MII entailed aspirating iliac crest bone marrow and peripheral blood, yielding mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) respectively, that were mixed with demineralized bone matrix (DBM) and injected under fluoroscopic control into the fracture site. No complications occurred in either group. The median time to union was 1.5 months in the MII group and 3 months in the control group. MII was found to be a safe and efficient procedure.",
author = "Meir Liebergall and Josh Schroeder and Rami Mosheiff and Zulma Gazit and Zilberman Yoram and Linda Rasooly and Anat Daskal and Amal Khoury and Yoram Weil and Shaul Beyth",
note = "Funding Information: We thank Alexandra Mahler and Shoshanah Kahn for their assistance in editing and formatting the manuscript. The study was supported by a grant from Teva Pharmaceutical Industries. This company is the recipient of a special grant from the Magnet Program of the Israel Ministry of Industry, Trade and Labor. This program is designated to support the formation of consortia made up of industrial companies and academic institutions. Our collaborating partner for this project was Teva Pharmaceutical Industries. Neither Teva nor the Israel Ministry of Industry played a role in writing either the study protocol or the investigators{\textquoteright} brochure. They did not analyze or interpret the data. The work was done at Jerusalem, Israel. The authors declare no conflict of interest. ",
year = "2013",
month = aug,
doi = "10.1038/mt.2013.109",
language = "אנגלית",
volume = "21",
pages = "1631--1638",
journal = "Molecular Therapy",
issn = "1525-0016",
publisher = "Cell Press",
number = "8",
}