Steady-state pattern electroretinogram and short-duration transient visual evoked potentials in glaucomatous and healthy eyes

Dilru C. Amarasekera, Arthur F. Resende, Michael Waisbourd, Sanjeev Puri, Marlene R. Moster, Lisa A. Hark, L. Jay Katz, Scott J. Fudemberg, Anand V. Mantravadi

Research output: Contribution to journalArticlepeer-review

Abstract

Importance: This study evaluates two rapid electrophysiological glaucoma diagnostic tests that may add a functional perspective to glaucoma diagnosis. Background: This study aimed to determine the ability of two office-based electrophysiological diagnostic tests, steady-state pattern electroretinogram and short-duration transient visual evoked potentials, to discern between glaucomatous and healthy eyes. Design: This is a cross-sectional study in a hospital setting. Participants: Forty-one patients with glaucoma and 41 healthy volunteers participated in the study. Methods: Steady-state pattern electroretinogram and short-duration transient visual evoked potential testing was conducted in glaucomatous and healthy eyes. A 64-bar-size stimulus with both a low-contrast and high-contrast setting was used to compare steady-state pattern electroretinogram parameters in both groups. A low-contrast and high-contrast checkerboard stimulus was used to measure short-duration transient visual evoked potential parameters in both groups. Main Outcome Measures: Steady-state pattern electroretinogram parameters compared were MagnitudeD, MagnitudeD/Magnitude ratio, and the signal-to-noise ratio. Short-duration transient visual evoked potential parameters compared were amplitude and latency. Results: MagnitudeD was significantly lower in glaucoma patients when using a low-contrast (P = 0.001) and high-contrast (P < 0.001) 64-bar-size steady-state pattern electroretinogram stimulus. MagnitudeD/Magnitude ratio and SNR were significantly lower in the glaucoma group when using a high-contrast 64-bar-size stimulus (P < 0.001 and P = 0.010, respectively). Short-duration transient visual evoked potential amplitude and latency were not significantly different between the two groups. Conclusions and relevance: Steady-state pattern electroretinogram was effectively able to discern between glaucomatous and healthy eyes. Steady-state pattern electroretinogram may thus have a role as a clinically useful electrophysiological diagnostic tool.

Original languageEnglish
Pages (from-to)54-61
Number of pages8
JournalClinical and Experimental Ophthalmology
Volume46
Issue number1
DOIs
StatePublished - 1 Jan 2018
Externally publishedYes

Keywords

  • glaucoma
  • short-duration transient visual evoked potentials
  • steady-state pattern electroretinogram

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