TY - JOUR
T1 - Status and access to the Collaborative Cross population
AU - Welsh, Catherine E.
AU - Miller, Darla R.
AU - Manly, Kenneth F.
AU - Wang, Jeremy
AU - McMillan, Leonard
AU - Morahan, Grant
AU - Mott, Richard
AU - Iraqi, Fuad A.
AU - Threadgill, David W.
AU - De Villena, Fernando Pardo Manuel
N1 - Funding Information:
The development of the CC-UNC population was supported by grants from the National Institutes of Health (U01CA134240, P50MH090338, P50HG006582, and U54AI081680); Ellison Medical Foundation (grant AG-IA-0202-05), and National Science Foundation (grants IIS0448392 and IIS0812464). Essential support was provided by the Dean of the UNC School of Medicine, the Lineberger Comprehensive Cancer Center at UNC (Core Grant CA016086 from the National Cancer Institute), and the University Cancer Research Fund from the state of North Carolina. The development of the CC-TAU population was supported by the Wellcome Trust grant 085906/Z08/Z, and the development and characterization of the CC-AUS population was supported by Geniad and grant #DP11010256 from the Australian Research Council. We acknowledge the exceptional contribution to the CC project from Gary Churchill.
PY - 2012/10
Y1 - 2012/10
N2 - The Collaborative Cross (CC) is a panel of recombinant inbred lines derived from eight genetically diverse laboratory inbred strains. Recently, the genetic architecture of the CC population was reported based on the genotype of a single male per line, and other publications reported incompletely inbred CC mice that have been used to map a variety of traits. The three breeding sites, in the US, Israel, and Australia, are actively collaborating to accelerate the inbreeding process through marker-assisted inbreeding and to expedite community access of CC lines deemed to have reached defined thresholds of inbreeding. Plans are now being developed to provide access to this novel genetic reference population through distribution centers. Here we provide a description of the distribution efforts by the University of North Carolina Systems Genetics Core, Tel Aviv University, Israel and the University of Western Australia.
AB - The Collaborative Cross (CC) is a panel of recombinant inbred lines derived from eight genetically diverse laboratory inbred strains. Recently, the genetic architecture of the CC population was reported based on the genotype of a single male per line, and other publications reported incompletely inbred CC mice that have been used to map a variety of traits. The three breeding sites, in the US, Israel, and Australia, are actively collaborating to accelerate the inbreeding process through marker-assisted inbreeding and to expedite community access of CC lines deemed to have reached defined thresholds of inbreeding. Plans are now being developed to provide access to this novel genetic reference population through distribution centers. Here we provide a description of the distribution efforts by the University of North Carolina Systems Genetics Core, Tel Aviv University, Israel and the University of Western Australia.
UR - http://www.scopus.com/inward/record.url?scp=84867333071&partnerID=8YFLogxK
U2 - 10.1007/s00335-012-9410-6
DO - 10.1007/s00335-012-9410-6
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AN - SCOPUS:84867333071
VL - 23
SP - 706
EP - 712
JO - Mammalian Genome
JF - Mammalian Genome
SN - 0938-8990
IS - 9-10
ER -