Statistical identification of delayed repolarization: Applicability in long QT syndrome (LQTS) population

S. Gottlieb, A. J. Moss, W. J. Hall, S. Choi, F. Badilini, M. L. Andrews, E. H. Locati, J. L. Robinson

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The objectives of this study were: to establish normal standards for QT intervals, based on a large normal population, using high-quality digitized electrocardiogram recordings, and a statistical probabilistic approach adjusting for heart-rate, age, and gender, and to apply this approach to the LQTS international registry. Based on digitized electrocardiogram recordings and multiregression methods adjusting the QT interval for RR interval, age, and gender, in normal population (N = 578) a measurement called adjusted QT (QTa) was determined. QTa is expressed in normal population standard deviation units, and in percentiles (%QTa). The QTa was applied to the LQTS multicenter registry (N = 2000), treating probands (N = 326), and family members (N = 1674) separately.

Original languageEnglish
Title of host publicationComputers in Cardiology
PublisherPubl by IEEE
Pages297-300
Number of pages4
ISBN (Print)081862485X
StatePublished - 1992
EventProceedings of the 18th Annual Conference on Computers in Cardiology - Venice, Italy
Duration: 23 Sep 199126 Sep 1991

Publication series

NameComputers in Cardiology
ISSN (Print)0276-6574

Conference

ConferenceProceedings of the 18th Annual Conference on Computers in Cardiology
CityVenice, Italy
Period23/09/9126/09/91

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